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Substance Name: Trametinib [USAN:INN]
RN: 871700-17-3
UNII: 33E86K87QN
InChIKey: LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. (NCI Thesaurus)

Molecular Formula

  • C26-H23-F-I-N5-O4

Molecular Weight

  • 615.3967
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Trametinib [USAN:INN]

Synonyms

  • GSK 1120212
  • GSK1120212
  • JTP 74057
  • JTP-74057
  • Mekinist
  • N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide
  • Trametinib
  • UNII-33E86K87QN

Systematic Names

  • Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)-
  • N-(3-{3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl}phenyl)acetamide

Registry Numbers

CAS Registry Number

  • 871700-17-3

FDA UNII

  • 33E86K87QN

Other Registry Number

  • 1204531-14-5

System Generated Number

  • 0871700173

Structure Descriptors

InChI

InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

InChIKey

LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Smiles

CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1Nc4ccc(I)cc4F)c5cccc(NC(=O)C)c5)C