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Substance Name: Trametinib [USAN:INN]
RN: 871700-17-3
UNII: 33E86K87QN
InChIKey: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Note
- NCI: An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. (NCI Thesaurus)
Molecular Formula
- C26-H23-F-I-N5-O4
Molecular Weight
- 615.3967
Classification Codes
- Antineoplastic
- Antineoplastic Agents
- Enzyme Inhibitors
- Protein Kinase Inhibitors
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Names and Synonyms
Name of Substance
- Trametinib [USAN:INN]
Synonyms
- GSK 1120212
- GSK-1120212
- GSK1120212
- JTP 74057
- JTP-74057
- JTP74057
- Mekinist
- N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide
- Trametinib
- UNII-33E86K87QN
Systematic Names
- Acetamide, N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-3,4,6,7-tetrahydro-6,8- dimethyl-2,4,7-trioxopyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)-
- N-(3-{3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl}phenyl)acetamide
Registry Numbers
CAS Registry Number
- 871700-17-3
FDA UNII
- 33E86K87QN
Other Registry Number
- 1204531-14-5
System Generated Number
- 0871700173