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Substance Name: Ritipenem acetoxymethyl ester
RN: 87238-52-6
UNII: F975H7YQX9
InChIKey: FZKGLCPKPZBGLX-ROXVQFJHSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H16-N2-O8-S

Molecular Weight

  • 360.3414
 
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Names and Synonyms

Name of Substance

  • FCE 22891
  • Ritipenem acetoxymethyl ester

Synonyms

  • Acetoxymethyl (5R,6S)-2-carbamoyloxymethyl-6-((1R)-hydroxyethyl)-2-penem-3-carboxylate
  • BRN 4723315
  • FCE 22891
  • UNII-F975H7YQX9

Systematic Name

  • 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-6-(1-hydroxyethyl)-7-oxo-, (acetyloxy)methyl ester, (5R-(5-alpha,6-alpha(R*)))-

Registry Numbers

CAS Registry Number

  • 87238-52-6

FDA UNII

  • F975H7YQX9

System Generated Number

  • 0087238526

Structure Descriptors

InChI

1S/C13H16N2O8S/c1-5(16)8-10(18)15-9(12(19)23-4-22-6(2)17)7(24-11(8)15)3-21-13(14)20/h5,8,11,16H,3-4H2,1-2H3,(H2,14,20)/t5-,8+,11-/m1/s1

InChIKey

FZKGLCPKPZBGLX-ROXVQFJHSA-N

Smiles

C[C@@H](O)[C@@H]1[C@H]2SC(=C(N2C1=O)C(=O)OCOC(=O)C)COC(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 4363mg/kg (4363mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Antimicrobial Chemotherapy. Vol. 23(Suppl,
rat LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Antimicrobial Chemotherapy. Vol. 23(Suppl,