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Substance Name: Ivacaftor [USAN:INN]
RN: 873054-44-5
UNII: 1Y740ILL1Z
InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-N

Note

  • A CFTR potentiator.

Molecular Formula

  • C24-H28-N2-O3

Molecular Weight

  • 392.4962
 

Classification Codes

  • Chloride Channel Agonists
  • Membrane Transport Modulators
  • Treatment of Cystic Fibrosis

Names and Synonyms

Name of Substance

  • Ivacaftor [USAN:INN]

Synonyms

  • Ivacaftor
  • Kalydeco
  • UNII-1Y740ILL1Z
  • VX 770
  • VX-770

Systematic Name

  • 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-

Registry Numbers

CAS Registry Number

  • 873054-44-5

FDA UNII

  • 1Y740ILL1Z

Other Registry Numbers

  • 1134822-00-6
  • 1174930-71-2

System Generated Number

  • 0873054445

Structure Descriptors

InChI

1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)

InChIKey

PURKAOJPTOLRMP-UHFFFAOYSA-N

Smiles

CC(C)(C)c1cc(c(NC(=O)C2=CNc3ccccc3C2=O)cc1O)C(C)(C)C