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Substance Name: Fidaxomicin [USAN:INN]
RN: 873857-62-6
UNII: Z5N076G8YQ
InChIKey: ZVGNESXIJDCBKN-UUEYKCAUSA-N

Note

  • Antibiotic from strain of Actinoplanes which inhibits nucleic acid polymerases.

Molecular Formula

  • C52-H74-Cl2-O18

Molecular Weight

  • 1058.0446
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Treatment and Prevention of Clostridium Difficile Infections (CDI)or Clostridium Difficile-Associated Diarrhea (CDAD)
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Names and Synonyms

Name of Substance

  • Fidaxomicin [USAN:INN]
  • Lipiarmycin

MeSH Heading

  • Fidaxomicin

Synonyms

  • BRN 5228707
  • Clostomicin B1
  • Dificid
  • Fidaxomicin
  • Lipiarmicin
  • Lipiarmycin
  • Lipiarmycin A 3
  • OPT 80
  • OPT-80
  • PAR 01
  • PAR 101
  • PAR-101
  • R-Tiacumicin B
  • Tiacumicin B
  • UNII-Z5N076G8YQ

Registry Numbers

CAS Registry Number

  • 873857-62-6

FDA UNII

  • Z5N076G8YQ

Other Registry Numbers

  • 55352-58-4
  • 56645-60-4
  • 750595-89-2

System Generated Number

  • 0873857626

Structure Descriptors

InChI

InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1

InChIKey

ZVGNESXIJDCBKN-UUEYKCAUSA-N

Smiles

CC[C@H]1\C=C(/C)\[C@@H](O)C\C=C\C=C(/CO[C@@H]2O[C@H](C)[C@@H](OC(=O)c3c(O)c(Cl)c(O)c(Cl)c3CC)[C@H](O)[C@@H]2OC)\C(=O)O[C@@H](C\C=C(/C)\C=C(/C)\[C@@H]1O[C@@H]4OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]4O)[C@@H](C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Journal of Antibiotics. Vol. 28, Pg. 253, 1975.