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Substance Name: Fidaxomicin [USAN:INN]
RN: 873857-62-6
UNII: Z5N076G8YQ
InChIKey: ZVGNESXIJDCBKN-UUEYKCAUSA-N
Note
- Antibiotic from strain of Actinoplanes which inhibits nucleic acid polymerases.
Molecular Formula
- C52-H74-Cl2-O18
Molecular Weight
- 1058.0446
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Treatment and Prevention of Clostridium Difficile Infections (CDI)or Clostridium Difficile-Associated Diarrhea (CDAD)
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Names and Synonyms
Name of Substance
- Fidaxomicin [USAN:INN]
- Lipiarmycin
MeSH Heading
- Fidaxomicin
Synonyms
- BRN 5228707
- Clostomicin B1
- Dificid
- Fidaxomicin
- Lipiarmicin
- Lipiarmycin
- Lipiarmycin A 3
- OPT 80
- OPT-80
- PAR 01
- PAR 101
- PAR-101
- R-Tiacumicin B
- Tiacumicin B
- UNII-Z5N076G8YQ
Registry Numbers
CAS Registry Number
- 873857-62-6
FDA UNII
- Z5N076G8YQ
Other Registry Numbers
- 55352-58-4
- 56645-60-4
- 750595-89-2
System Generated Number
- 0873857626
Structure Descriptors
InChI
InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1InChIKey
ZVGNESXIJDCBKN-UUEYKCAUSA-NSmiles
CC[C@H]1\C=C(/C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | Journal of Antibiotics. Vol. 28, Pg. 253, 1975. |