Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: 2-Demethylthiocolchicine
RN: 87424-26-8
InChIKey: OMQLBXIHBJAOIO-HNNXBMFYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H23-N-O5-S

Molecular Weight

  • 401.4807
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • 2-Demethylthiocolchicine

Synonyms

  • 2-Demethylthiocolchicine
  • 4-14-00-00957 (Beilstein Handbook Reference)
  • BRN 3176298
  • NSC 369937
  • O(sup 2)-Demethyl-10-thiocolchicine

Systematic Name

  • Colchicine, O(sup 2)-demethyl-10-thio-

Registry Numbers

CAS Registry Number

  • 87424-26-8

System Generated Number

  • 0087424268

Structure Descriptors

InChI

1S/C21H23NO5S/c1-11(23)22-15-7-5-12-9-17(26-2)20(25)21(27-3)19(12)13-6-8-18(28-4)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1

InChIKey

OMQLBXIHBJAOIO-HNNXBMFYSA-N

Smiles

COc1cc2CC[C@H](NC(=O)C)C3=CC(=O)C(=CC=C3c2c(OC)c1O)SC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 30mg/kg (30mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LDLo intracrebral 25ug/kg (0.025mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.