Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Trandolapril [USP:INN:BAN]
RN: 87679-37-6
UNII: 1T0N3G9CRC
InChIKey: VXFJYXUZANRPDJ-WTNASJBWSA-N

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Protease Inhibitors
  • Reproductive Effect

Molecular Formula

  • C24-H34-N2-O5

Molecular Weight

  • 430.5416
 

Names and Synonyms

Name of Substance

  • Trandolapril
  • Trandolapril [USP:INN:BAN]

Synonyms

  • (2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
  • CCRIS 6594
  • Gopten
  • Mavik
  • Odrik
  • RU 44570
  • Trandolapril
  • Trandolaprilum
  • Trandolaprilum [Latin]
  • UNII-1T0N3G9CRC

Systematic Names

  • (2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
  • 1H-Indole-2-carboxylic acid, 1-((2S)-2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3aR,7aS)-
  • 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-alpha,7a-beta))-
  • Trandolapril

Registry Numbers

CAS Registry Number

  • 87679-37-6

FDA UNII

  • 1T0N3G9CRC

System Generated Number

  • 0087679376

Structure Descriptors

InChI

1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1

InChIKey

VXFJYXUZANRPDJ-WTNASJBWSA-N

Smiles

CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse LD50 intraperitoneal 1285mg/kg (1285mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse LD50 intravenous 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse LD50 oral 3990mg/kg (3990mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat LD50 intraperitoneal 1420mg/kg (1420mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat LD50 intravenous > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat LD50 oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.