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Substance Name: Crizotinib [USAN:INN]
RN: 877399-52-5
UNII: 53AH36668S
InChIKey: KTEIFNKAUNYNJU-GFCCVEGCSA-N
Notes
- A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
- A selective c-Met/Alk tyrosine kinase inhibitor in clinical development as an anticancer agent (5/2010).
NCI: An orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-02341066 inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations.
Molecular Formula
- C21-H22-Cl2-F-N5-O
Molecular Weight
- 450.3428
Classification Codes
- Antineoplastic Agents
- Enzyme Inhibitors
- Oncology
- Protein Kinase Inhibitors
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Names and Synonyms
Name of Substance
- Crizotinib [USAN:INN]
MeSH Heading
- Crizotinib
Synonyms
- Crizotinib
- NSC 756645
- PF 02341066
- PF 2341066
- PF-02341066
- PF-2341066
- UNII-53AH36668S
- Xalkori
Systematic Name
- 2-Pyridinamine, 3-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(4-piperidinyl)-1H-pyrazol-4-yl)-
Registry Numbers
CAS Registry Number
- 877399-52-5
FDA UNII
- 53AH36668S
Other Registry Number
- 912279-98-2
System Generated Number
- 0877399525