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Substance Name: Crizotinib [USAN:INN]
RN: 877399-52-5
UNII: 53AH36668S
InChIKey: KTEIFNKAUNYNJU-GFCCVEGCSA-N

Note

  • A selective c-Met/Alk tyrosine kinase inhibitor in clinical development as an anticancer agent (5/2010).

    NCI: An orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-02341066 inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations.

Molecular Formula

  • C21-H22-Cl2-F-N5-O

Molecular Weight

  • 450.3428
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Oncology
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Crizotinib [USAN:INN]

MeSH Heading

  • Crizotinib

Synonyms

  • Crizotinib
  • PF 02341066
  • PF 2341066
  • PF-02341066
  • PF-2341066
  • UNII-53AH36668S
  • Xalkori

Systematic Name

  • 2-Pyridinamine, 3-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(4-piperidinyl)-1H-pyrazol-4-yl)-

Registry Numbers

CAS Registry Number

  • 877399-52-5

FDA UNII

  • 53AH36668S

Other Registry Number

  • 912279-98-2

System Generated Number

  • 0877399525

Structure Descriptors

InChI

1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChIKey

KTEIFNKAUNYNJU-GFCCVEGCSA-N

Smiles

C[C@H](c1c(ccc(c1Cl)F)Cl)Oc2cc(cnc2N)c3cnn(c3)C4CCNCC4