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Substance Name: Crizotinib [USAN:INN]
RN: 877399-52-5
UNII: 53AH36668S
InChIKey: KTEIFNKAUNYNJU-GFCCVEGCSA-N

Notes

  • A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
  • A selective c-Met/Alk tyrosine kinase inhibitor in clinical development as an anticancer agent (5/2010).

    NCI: An orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-02341066 inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations.

Molecular Formula

  • C21-H22-Cl2-F-N5-O

Molecular Weight

  • 450.3428
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Oncology
  • Protein Kinase Inhibitors

Names and Synonyms

Name of Substance

  • Crizotinib [USAN:INN]

MeSH Heading

  • Crizotinib

Synonyms

  • Crizotinib
  • NSC 756645
  • PF 02341066
  • PF 2341066
  • PF-02341066
  • PF-2341066
  • UNII-53AH36668S
  • Xalkori

Systematic Name

  • 2-Pyridinamine, 3-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(4-piperidinyl)-1H-pyrazol-4-yl)-

Registry Numbers

CAS Registry Number

  • 877399-52-5

FDA UNII

  • 53AH36668S

Other Registry Number

  • 912279-98-2

System Generated Number

  • 0877399525

Structure Descriptors

InChI

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChIKey

KTEIFNKAUNYNJU-GFCCVEGCSA-N

Smiles

C[C@@H](Oc1cc(cnc1N)c2cnn(c2)C3CCNCC3)c4c(Cl)ccc(F)c4Cl