Substance Name: Crizotinib acetate
- A selective c-Met/Alk tyrosine kinase inhibitor in clinical development as an anticancer agent (5/2010).
NCI: An orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-02341066 inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations.
- Kinase Inhibitors
- Protein Kinase Inhibitors
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- Crizotinib acetate
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