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Substance Name: Crizotinib acetate
RN: 877399-53-6
InChIKey: LFCVDLCLKZRGFW-UTONKHPSSA-N

Note

  • A selective c-Met/Alk tyrosine kinase inhibitor in clinical development as an anticancer agent (5/2010).

    NCI: An orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-02341066 inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations.

Molecular Formula

  • C21-H22-Cl2-F-N5-O.C2-H4-O2

Molecular Weight

  • 510.3944
 

Classification Codes

  • Kinase Inhibitors
  • Protein Kinase Inhibitors
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Names and Synonyms

  • Crizotinib acetate

Registry Numbers

CAS Registry Number

  • 877399-53-6

System Generated Number

  • 0877399536

Structure Descriptors

InChI

1S/C21H22Cl2FN5O.C2H4O2/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15;1-2(3)4/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27);1H3,(H,3,4)/t12-;/m1./s1

InChIKey

LFCVDLCLKZRGFW-UTONKHPSSA-N

Smiles

C[C@H](c1c(ccc(c1Cl)F)Cl)Oc2cc(cnc2N)c3cnn(c3)C4CCNCC4.CC(=O)O