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Substance Name: Porfimer sodium [USAN:INN:BAN]
RN: 87806-31-3
UNII: Y3834SIK5F
InChIKey: RSQDGTJKZWTAGL-DRLFZNBHSA-N

Note

  • The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.

Molecular Formula

  • Unspecified

Molecular Weight

  • 605.6872
 

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Porfimer sodium [USAN:INN:BAN]

Synonyms

  • CL 184,116
  • CL 184116
  • DHE
  • Photofrin 2
  • Photofrin II
  • Polyhematoporphyrin ether
  • Porfimer sodico
  • Porfimer sodico [INN-Spanish]
  • Porfimer Sodium
  • Porfimere sodique
  • Porfimere sodique [INN-French]
  • Porfimerum natricum
  • Porfimerum natricum [INN-Latin]
  • UNII-Y3834SIK5F

Systematic Names

  • Photofrin II
  • Photofrin Porfimer sodium

Registry Numbers

CAS Registry Number

  • 87806-31-3

FDA UNII

  • Y3834SIK5F

System Generated Number

  • 0087806313

Structure Descriptors

InChI

1S/C34H38N4O5.Na/c1-7-21-16(2)24-12-25-17(3)22(8-10-32(40)41)29(36-25)15-30-23(9-11-33(42)43)18(4)26(37-30)14-31-34(20(6)39)19(5)27(38-31)13-28(21)35-24;/h12-15,20,35,37,39H,7-11H2,1-6H3,(H,40,41)(H,42,43);/q;+1/b24-12-,25-12-,26-14-,27-13-,28-13-,29-15-,30-15-,31-14-;

InChIKey

RSQDGTJKZWTAGL-DRLFZNBHSA-N

Smiles

CCc\1c(/c/2c/c3n/c(c\c4c(c(c([nH]4)/cc/5\nc(/cc1\[nH]2)C(=C5C(C)O)C)C)CCC(=O)O)/C(=C3C)CCC(=O)O)C.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 439, 1995.
mouse LD50 intravenous > 125mg/kg (125mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 439, 1995.
rat LD50 intravenous 75mg/kg (75mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 439, 1995.