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Substance Name: Awamycin
RN: 87913-35-7
InChIKey: WZCNXFSCUFEMGW-UMLOSGLNSA-N

Note

  • Isolated from Streptomyces sp. No. 80-217.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C38-H49-N-O12-S

Molecular Weight

  • 743.866
 
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Names and Synonyms

Name of Substance

  • Awamycin

Synonyms

  • Antibiotic Tan 528A
  • Awamycin
  • TAN 528A

Systematic Names

  • Protostreptovaricin I, 10,25-didemethyl-21-hydroxy-10-(methoxycarbonyl)-19-O-methyl-25-(methylthio)-
  • Protostreptovaricin-31-oic acid, 25-demethyl-21-hydroxy-19-O-methyl-2S-(methylthio)-, methyl ester

Registry Numbers

CAS Registry Number

  • 87913-35-7

System Generated Number

  • 0087913357

Structure Descriptors

InChI

1S/C38H49NO12S/c1-15-12-11-13-16(2)37(48)39-26-33(46)23-22(34(47)36(26)52-10)24(35(50-8)21(7)32(23)45)29(42)18(4)14-17(3)28(41)20(6)31(44)25(38(49)51-9)30(43)19(5)27(15)40/h11-15,17,19-20,25,27-28,30-31,40-41,43-45H,1-10H3,(H,39,48)/b12-11+,16-13-,18-14-

InChIKey

WZCNXFSCUFEMGW-UMLOSGLNSA-N

Smiles

C1=CC=C(C(NC2=C(C(=O)c3c(C(C(=C[C@@H](C)[C@@H]([C@@H](C)[C@@H]([C@@H]([C@@H](O)[C@@H](C)[C@@H]([C@@H]1C)O)C(OC)=O)O)O)C)=O)c(c(C)c(c3C2=O)O)OC)SC)=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 unreported 25mg/kg (25mg/kg)   Journal of Antibiotics. Vol. 37, Pg. 84-144, 1984.