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Substance Name: Pilsicainide hydrochloride [JAN]
RN: 88069-49-2
UNII: 03C8I9296V
InChIKey: NZOSVDHCTCLGEB-UHFFFAOYSA-N

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Sodium Channel Blockers

Molecular Formula

  • C17-H24-N2-O.Cl-H

Molecular Weight

  • 308.85
 
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Names and Synonyms

Name of Substance

  • Pilsicainide
  • Pilsicainide hydrochloride
  • Pilsicainide hydrochloride [JAN]

Synonyms

  • 1H-Pyrrolizine-8-acetamide, hexahydro-N-(2,6-dimethylphenyl)-, hydrochloride
  • N-(2,6-Dimethylphenyl)-1H-pyrrolizine-8-acetamide hydrochloride
  • N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide monohydrochloride
  • Pilsicainide HCl
  • Pilsicainide hydrochloride
  • SUN 1165
  • Sunrythm
  • UNII-03C8I9296V

Systematic Name

  • 1H-Pyrrolizine-7a(5H)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 88069-49-2

FDA UNII

  • 03C8I9296V

System Generated Number

  • 0088069492

Molecular Formulas

Molecular Formula

  • C17-H24-N2-O.Cl-H

Molecular Formula Fragments

  • C17-H24-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H

InChIKey

NZOSVDHCTCLGEB-UHFFFAOYSA-N

Smiles

C1CN2CCCC2(C1)CC(Nc1c(cccc1C)C)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 18mg/kg (18mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 461, 1991.
dog LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse LD50 oral 175mg/kg (175mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse LD50 subcutaneous 410mg/kg (410mg/kg)   Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit LD50 oral 87mg/kg (87mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
rat LD50 intraperitoneal 105mg/kg (105mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
rat LD50 intravenous 18mg/kg (18mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
rat LD50 oral 255mg/kg (255mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.