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Substance Name: Amlodipine [INN:BAN]
RN: 88150-42-9
UNII: 1J444QC288
InChIKey: HTIQEAQVCYTUBX-UHFFFAOYSA-N

Note

  • A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of angina pectoris and hypertension.

Molecular Formula

  • C20-H25-Cl-N2-O5

Molecular Weight

  • 408.8795
 

Classification Codes

  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Calcium-Regulating Hormones and Agents
  • Cardiovascular Agents
  • Membrane Transport Modulators
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Amlodipine
  • Amlodipine [INN:BAN]

MeSH Heading

  • Amlodipine

Synonyms

  • 3-Ethyl-5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat
  • 3-Ethyl-5-methyl (+-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
  • Amlocard
  • Amlodipine
  • Amlodipino
  • Amlodipino [Spanish]
  • Amlodipinum
  • Amlodipinum [Latin]
  • Amlodis
  • Amlor
  • Coroval
  • EC 425-820-1
  • HSDB 7079
  • Lipinox
  • Norvasc
  • UNII-1J444QC288

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
  • 3-Ethyl 5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Mixture Names

  • Exforge
  • Lotrel

Registry Numbers

CAS Registry Number

  • 88150-42-9

FDA UNII

  • 1J444QC288

Related Registry Number

  • 88150-47-4 (maleate (1:1))

System Generated Number

  • 0088150429

Structure Descriptors

InChI

InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3

InChIKey

HTIQEAQVCYTUBX-UHFFFAOYSA-N

Smiles

CCOC(=O)C1=C(COCCN)NC(=C(C1c2ccccc2Cl)C(=O)OC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 400ug/kg (0.4mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION American Journal of Emergency Medicine. Vol. 18, Pg. 581, 2000.
women LDLo oral 1400ug/kg (1.4mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 253, 1995.
women TDLo oral 600ug/kg/3D-I (0.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BLOOD: THROMBOCYTOPENIA

BLOOD: HEMORRHAGE		 Annals of Pharmacotherpy. Vol. 33, Pg. 1126, 1999.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3 (none)   EXP
Water Solubility 75.3 mg/L 25 EST
Vapor Pressure 1.19E-09 mm Hg 25 EST
Henry's Law Constant 2.91E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.79E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.