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Substance Name: Amlodipine [INN:BAN]
RN: 88150-42-9
UNII: 1J444QC288
InChIKey: HTIQEAQVCYTUBX-UHFFFAOYSA-N
Note
- A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of angina pectoris and hypertension.
Molecular Formula
- C20-H25-Cl-N2-O5
Molecular Weight
- 408.8795
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Amlodipine
- Amlodipine [INN:BAN]
MeSH Heading
- Amlodipine
Synonyms
- 3-Ethyl-5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat
- 3-Ethyl-5-methyl (+-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
- Amlocard
- Amlodipine
- Amlodipino
- Amlodipino [Spanish]
- Amlodipinum
- Amlodipinum [Latin]
- Amlodis
- Amlor
- Coroval
- EC 425-820-1
- HSDB 7079
- Lipinox
- Norvasc
- UNII-1J444QC288
Systematic Names
- 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
- 3-Ethyl 5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
Mixture Names
- Exforge
- Lotrel
Registry Numbers
CAS Registry Number
- 88150-42-9
FDA UNII
- 1J444QC288
Related Registry Number
- 88150-47-4 (maleate (1:1))
System Generated Number
- 0088150429
Structure Descriptors
InChI
1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3InChIKey
HTIQEAQVCYTUBX-UHFFFAOYSA-NSmiles
CCOC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 400ug/kg (0.4mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | American Journal of Emergency Medicine. Vol. 18, Pg. 581, 2000. |
| women | LDLo | oral | 1400ug/kg (1.4mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 253, 1995. |
| women | TDLo | oral | 600ug/kg/3D-I (0.6mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BLOOD: THROMBOCYTOPENIA BLOOD: HEMORRHAGE | Annals of Pharmacotherpy. Vol. 33, Pg. 1126, 1999. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 3 | (none) | EXP | |
| Water Solubility | 75.3 | mg/L | 25 | EST |
| Vapor Pressure | 1.19E-09 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.91E-17 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.79E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.