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Substance Name: Larazotide acetate [USAN]
RN: 881851-50-9
UNII: FO8S2IW40N
InChIKey: NYGCNONRVCGHAT-UFIKZEAMSA-N

Notes

  • An octapeptide inhibitor of paracellular permeability whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease.
  • An octapeptide inhibitor of paracellular permeability whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease; do not confuse with AT1001 deoxyjirimycin.

Molecular Formula

  • C32-H55-N9-O10.C2-H4-O2

Molecular Weight

  • 785.8911
 

Classification Codes

  • Treatment of Celiac Disease
  • Treatment of Celiac Disease and Treatment of Inflammatory Bowel Disease
  • Treatment of Inflammatory Bowel Disease
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Names and Synonyms

Name of Substance

  • Larazotide acetate [USAN]

Synonyms

  • AT 1001
  • AT-1001
  • Glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolylglycine acetate
  • Larazotide acetate
  • UNII-FO8S2IW40N

Systematic Name

  • Glycine, glycylglycyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-prolyl-, monoacetate

Registry Numbers

CAS Registry Number

  • 881851-50-9

FDA UNII

  • FO8S2IW40N

System Generated Number

  • 0881851509

Structure Descriptors

InChI

1S/C32H55N9O10.C2H4O2/c1-16(2)12-20(38-30(49)26(17(3)4)39-24(44)14-35-23(43)13-33)28(47)40-27(18(5)6)31(50)37-19(9-10-22(34)42)32(51)41-11-7-8-21(41)29(48)36-15-25(45)46;1-2(3)4/h16-21,26-27H,7-15,33H2,1-6H3,(H2,34,42)(H,35,43)(H,36,48)(H,37,50)(H,38,49)(H,39,44)(H,40,47)(H,45,46);1H3,(H,3,4)/t19-,20-,21-,26-,27-;/m0./s1

InChIKey

NYGCNONRVCGHAT-UFIKZEAMSA-N

Smiles

CC(C)C[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)CN)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O.CC(=O)O