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Substance Name: Clofibric acid [INN:DCF]
RN: 882-09-7
UNII: 53PF01Q249
InChIKey: TXCGAZHTZHNUAI-UHFFFAOYSA-N

Note

  • An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.

Molecular Formula

  • C10-H11-Cl-O3

Molecular Weight

  • 214.6469
 

Classification Codes

  • Anticholesteremic Agents
  • Antimetabolites
  • Drug / Therapeutic Agent
  • Human Data
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Clofibric acid
  • Clofibric acid [INN:DCF]

MeSH Heading

  • Clofibric acid

Synonyms

  • 2-(4-Chlorophenoxy)-2-methylpropanoic acid
  • 2-(4-Chlorophenoxy)-2-methylpropionic acid
  • 2-(p-Chlorophenoxy)-2-methylpropionic acid
  • 2-(p-Chlorophenoxy)isobutyric acid
  • 4-(Chlorophenoxy)isobutyric acid (VAN)
  • 4-06-00-00851 (Beilstein Handbook Reference)
  • Acetic acid, (p-chlorophenoxy)dimethyl-
  • Acide (p-chlorophenoxy)-2 methyl-2 propionique
  • Acide (p-chlorophenoxy)-2 methyl-2 propionique [French]
  • Acide clofibrique
  • Acide clofibrique [INN-French]
  • Acido clofibrico
  • Acido clofibrico [INN-Spanish]
  • Acidum chlorphibricum
  • Acidum clofibricum
  • Acidum clofibricum [INN-Latin]
  • alpha-(4-(Chlorphenoxy)-2-methylpropionsaeure
  • alpha-(4-Chlorophenoxy)-alpha-methylpropionic acid
  • alpha-(4-Chlorophenoxy)isobutyric acid
  • alpha-(p-Chlorophenoxy)isobutyric acid
  • BRN 1874067
  • CCRIS 9254
  • Chlorfibrinic acid
  • Chlorofibrinic acid
  • Chlorophibrinic acid
  • Clofibrate free acid
  • Clofibric acid
  • Clofibrin
  • Clofibrinic acid
  • Clofibrinsaeure
  • Clofibrinsaeure [German]
  • EINECS 212-925-9
  • NSC 1149
  • NSC-1149
  • p-(2,4-Chlorophenoxy)isobutyric acid
  • Regadrin
  • Regulipid
  • UNII-53PF01Q249

Systematic Names

  • 2-(p-Chlorophenoxy)-2-methylpropionic acid
  • Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-
  • Propionic acid, 2-(p-chlorophenoxy)-2-methyl-

Registry Numbers

CAS Registry Number

  • 882-09-7

FDA UNII

  • 53PF01Q249

System Generated Number

  • 0000882097

Structure Descriptors

InChI

1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)

InChIKey

TXCGAZHTZHNUAI-UHFFFAOYSA-N

Smiles

CC(C)(C(=O)O)Oc1ccc(cc1)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo unreported 260mg/kg/91D (260mg/kg) LIVER: OTHER CHANGES Atherosclerosis Vol. 36, Pg. 159, 1980.
mouse LD50 intraperitoneal 290mg/kg (290mg/kg)   Pharmazie. Vol. 22, Pg. 167, 1967.
mouse LD50 oral 1170mg/kg (1170mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1173, 1977.
mouse LD50 subcutaneous 683mg/kg (683mg/kg)   Russian Pharmacology and Toxicology Vol. 33, Pg. 150, 1970.
rat LD50 intraperitoneal 727mg/kg (727mg/kg)   Travaux de la Societe de Pharmacie de Montpellier. Vol. 34, Pg. 121, 1974.
rat LD50 oral 897mg/kg (897mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 2023, 1980.
rat LD50 subcutaneous 120mg/kg (120mg/kg)   Pharmazie. Vol. 22, Pg. 167, 1967.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 118-119 deg C   EXP
log P (octanol-water) 2.57 (none)   EXP
Water Solubility 583 mg/L 25 EST
Vapor Pressure 1.13E-04 mm Hg 25 EST
Henry's Law Constant 2.19E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.75E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.