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Substance Name: Transcainide [USAN:INN]
RN: 88296-62-2
UNII: 5VSP2X37QG
InChIKey: MFKCGXDCHAFQQZ-RTBURBONSA-N

Classification Codes

  • Cardiac Depressant (Anti-Arrhythmic)
  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H35-N3-O2

Molecular Weight

  • 373.5375
 
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Names and Synonyms

Name of Substance

  • Transcainide
  • Transcainide [USAN:INN]

Synonyms

  • (+-)-trans-4-(Dimethylamino)-1-(2-hydroxycyclohexyl)-2',6'-isonipectoxylidide
  • R 54,718
  • Transcainida
  • Transcainida [Spanish]
  • Transcainide
  • Transcainidum
  • Transcainidum [Latin]
  • UNII-5VSP2X37QG

Systematic Name

  • 4-Piperidinecarboxamide, 4-(dimethylamino)-N-(2,6-dimethylphenyl)-1-(2-hydroxycyclohexyl)-, trans-(+-)-

Registry Numbers

CAS Registry Number

  • 88296-62-2

FDA UNII

  • 5VSP2X37QG

System Generated Number

  • 0088296622

Structure Descriptors

InChI

1S/C22H35N3O2/c1-16-8-7-9-17(2)20(16)23-21(27)22(24(3)4)12-14-25(15-13-22)18-10-5-6-11-19(18)26/h7-9,18-19,26H,5-6,10-15H2,1-4H3,(H,23,27)/t18-,19-/m1/s1

InChIKey

MFKCGXDCHAFQQZ-RTBURBONSA-N

Smiles

Cc1cccc(c1NC(=O)C2(CCN(CC2)[C@@H]3CCCC[C@H]3O)N(C)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 440ug/kg (0.44mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 287, Pg. 272, 1987.
dog LD50 oral 1500ug/kg (1.5mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 287, Pg. 272, 1987.
rat LD50 intravenous 440ug/kg (0.44mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 287, Pg. 272, 1987.
rat LD50 oral 4830ug/kg (4.83mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 287, Pg. 272, 1987.