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Substance Name: Pegloticase [USAN:INN]
RN: 885051-90-1


  • Uricase covalently attached to polyethylene glycol, modifying 71% of amino groups & retaining 11% of activity without eliciting antibody response in mice or man; used for lowering serum uric acid.

Molecular Formula

  • C1549-H2430-N408-O448-S8

Classification Code

  • Treatment of Chronic Gout in Patients Refractory to Conventional Therapy

Names and Synonyms

Name of Substance

  • Pegloticase
  • Pegloticase [USAN:INN]


  • des-(1-5)-(6-Threonine,45-threonine,290-lysine,300-serine)uricase (EC,urate oxidase) from Sus scrofa (Pig), tetramer
  • HSDB 8391
  • Krystexxa
  • Methoxypolyethylene glycol uricase
  • PEG-uricase
  • Pegloticase
  • Polyethylene glycol-uricase
  • Puricase
  • UNII-R581OT55EA

Systematic Name

  • Oxidase, urate (synthetic Sus scrofa domestica variant pigKS-deltaN subunit), homotetramer, compd. with poly(oxy-1,2-ethanediyl)

Registry Numbers

CAS Registry Number

  • 885051-90-1


  • R581OT55EA

System Generated Number

  • 0885051901