Substance Name: Pegloticase [USAN:INN]
RN: 885051-90-1
UNII: R581OT55EA
Note
- Uricase covalently attached to polyethylene glycol, modifying 71% of amino groups & retaining 11% of activity without eliciting antibody response in mice or man; used for lowering serum uric acid.
Molecular Formula
- C1549-H2430-N408-O448-S8
Classification Code
- Treatment of Chronic Gout in Patients Refractory to Conventional Therapy
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Pegloticase
- Pegloticase [USAN:INN]
Synonyms
- des-(1-5)-(6-Threonine,45-threonine,290-lysine,300-serine)uricase (EC 1.7.3.3,urate oxidase) from Sus scrofa (Pig), tetramer
- Krystexxa
- Methoxypolyethylene glycol uricase
- Pegloticase
- Polyethylene glycol-uricase
- Puricase
- UNII-R581OT55EA
Systematic Name
- Oxidase, urate (synthetic Sus scrofa domestica variant pigKS-deltaN subunit), homotetramer, compd. with poly(oxy-1,2-ethanediyl)
Registry Numbers
CAS Registry Number
- 885051-90-1
FDA UNII
- R581OT55EA
System Generated Number
- 0885051901