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Substance Name: Chlorphenesin carbamate [USAN:JAN]
RN: 886-74-8
UNII: 57U5YI11WP
InChIKey: SKPLBLUECSEIFO-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Relaxant (Skeletal Muscle)
  • Reproductive Effect

Molecular Formula

  • C10-H12-Cl-N-O4

Molecular Weight

  • 245.6608
 
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Names and Synonyms

Name of Substance

  • Chlorphenesin carbamate
  • Chlorphenesin carbamate [USAN:JAN]

Synonyms

  • 1,2-Propanediol, 3-(p-chlorophenoxy)-, 1-carbamate
  • 3-(4-Chlorophenoxy)-1,2-propanediol-1-carbamate
  • 3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate
  • 3-(p-Chlorophenoxy)-1,2-propanediol 1-carbamate
  • 3-(p-Chlorophenoxy)-1,2-propanediol-1-carbamate
  • 3-(p-Chlorophenoxy)-2-hydroxypropyl carbamate
  • Adermykon
  • BRN 1978575
  • Carbamic acid, 3-(p-chlorophenoxy)-2-hydroxypropyl ester
  • Chlorphenesin carbamate
  • EINECS 212-954-7
  • HSDB 3031
  • Kolpicortin-sine
  • Maolate
  • NSC 82943
  • Rinlaxer
  • U 19646
  • U-19,646
  • UNII-57U5YI11WP

Systematic Names

  • 1,2-Propanediol, 3-(4-chlorophenoxy)-, 1-carbamate
  • 1,2-Propanediol, 3-(p-chlorophenoxy)-, 1-carbamate (8CI)
  • 3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate
  • Carbamic acid, 3-(p-chlorophenoxy)-2-hydroxypropyl ester

Registry Numbers

CAS Registry Number

  • 886-74-8

FDA UNII

  • 57U5YI11WP

System Generated Number

  • 0000886748

Structure Descriptors

InChI

1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)

InChIKey

SKPLBLUECSEIFO-UHFFFAOYSA-N

Smiles

NC(=O)OCC(O)COc1ccc(Cl)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 23mg/kg/D (23mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: MUSCLE WEAKNESS
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 171, 1969.
mammal (species unspecified) LD50 oral 800mg/kg (800mg/kg)   Farmaco, Edizione Scientifica. Vol. 27, Pg. 870, 1972.
mouse LD50 intraperitoneal 475mg/kg (475mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 659, 1977.
mouse LD50 intravenous 239mg/kg (239mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 386, 1972.
mouse LD50 oral 807mg/kg (807mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 659, 1977.
mouse LD50 subcutaneous 923mg/kg (923mg/kg)   Drugs in Japan Vol. -, Pg. 437, 1995.
rat LD50 intraperitoneal 354mg/kg (354mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 386, 1972.
rat LD50 intravenous 236mg/kg (236mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 1163, 1979.
rat LD50 oral 744mg/kg (744mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 659, 1977.
rat LD50 subcutaneous 952mg/kg (952mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 659, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 90 deg C   EXP
log P (octanol-water) 0.820 (none)   EST
Atmospheric OH Rate Constant 3.19E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.