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Substance Name: Liranaftate [INN]
RN: 88678-31-3
UNII: 5253IGO5X3
InChIKey: VPHPQNGOVQYUMG-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H20-N2-O2-S

Molecular Weight

  • 328.434
 
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Names and Synonyms

Name of Substance

  • Liranaftate
  • Liranaftate [INN]

Synonyms

  • Liranaftate
  • Liranaftato
  • Liranaftato [INN-Spanish]
  • Liranaftatum
  • Liranaftatum [INN-Latin]
  • M-732
  • Piritetrate
  • UNII-5253IGO5X3

Systematic Names

  • Carbamothioic acid, (6-methoxy-2-pyridinyl)methyl-, O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester
  • O-(5,6,7,8,-Tetrahydro-2-naphthyl) 6-methoxy-N-methylthio-2-pyridinecarbamate

Registry Numbers

CAS Registry Number

  • 88678-31-3

FDA UNII

  • 5253IGO5X3

System Generated Number

  • 0088678313

Structure Descriptors

InChI

1S/C18H20N2O2S/c1-20(16-8-5-9-17(19-16)21-2)18(23)22-15-11-10-13-6-3-4-7-14(13)12-15/h5,8-12H,3-4,6-7H2,1-2H3

InChIKey

VPHPQNGOVQYUMG-UHFFFAOYSA-N

Smiles

C1CCc2c(C1)cc(OC(N(c1cccc(n1)OC)C)=S)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg) BLOOD: CHANGES IN SPLEEN

LIVER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
rat LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 281, 1993.