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Substance Name: Ganetespib [USAN:INN]
RN: 888216-25-9
UNII: 2E8412Y946
InChIKey: RVAQIUULWULRNW-UHFFFAOYSA-N

Note

  • NCI: A synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. (NCI Thesaurus)

Molecular Formula

  • C20-H20-N4-O3

Molecular Weight

  • 364.403
 

Classification Code

  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Ganetespib [USAN:INN]

Synonyms

  • 5-(2,4-Dihydroxy-5-(1-methylethyl)phenyl)-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H- 1,2,4-triazol-3-one
  • Ganetespib
  • STA 9090
  • STA-9090
  • STA9090
  • UNII-2E8412Y946

Systematic Name

  • 3H-1,2,4-Triazol-3-one, 5-(2,4-dihydroxy-5-(1-methylethyl)phenyl)-2,4-dihydro-4-(1- methyl-1H-indol-5-yl)-

Registry Numbers

CAS Registry Number

  • 888216-25-9

FDA UNII

  • 2E8412Y946

Other Registry Number

  • 1143571-94-1

System Generated Number

  • 0888216259

Structure Descriptors

InChI

InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)

InChIKey

RVAQIUULWULRNW-UHFFFAOYSA-N

Smiles

CC(C)c1cc(C2=NNC(=O)N2c3ccc4c(ccn4C)c3)c(O)cc1O