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Substance Name: Clinprost [INN]
RN: 88931-51-5
UNII: 6GRI2J11N5
InChIKey: QIGRQPVOWVHYBT-KABTVRTISA-N

Molecular Formula

  • C22-H36-O4

Molecular Weight

  • 364.522
 
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Names and Synonyms

Name of Substance

  • Clinprost [INN]
  • TEI 9090
  • TTC 909

Synonyms

  • (+)-Methyl-(3aS,5R,6R,6aS)-1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-((E)-(3S)-3-hydroxy-1-octenyl)-2-pentalenevalerate
  • Clinprost
  • Isocarbacyclin methyl ester
  • TEI 9090
  • TTC 909
  • UNII-6GRI2J11N5

Systematic Names

  • (+)-Methyl-(3aS,5R,6R,6aS)-1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-((E)-(3S)-3-hydroxy-1-octenyl)-2-pentalenevalerate
  • 2-Pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-, methyl ester, (3aS-(3a-alpha,5-beta,6-alpha(1E,3R*),6a-alpha))-

Registry Numbers

CAS Registry Number

  • 88931-51-5

FDA UNII

  • 6GRI2J11N5

System Generated Number

  • 0088931515

Structure Descriptors

InChI

1S/C22H36O4/c1-3-4-5-9-18(23)11-12-19-20-14-16(13-17(20)15-21(19)24)8-6-7-10-22(25)26-2/h11-13,17-21,23-24H,3-10,14-15H2,1-2H3/b12-11+/t17-,18-,19+,20-,21+/m0/s1

InChIKey

QIGRQPVOWVHYBT-KABTVRTISA-N

Smiles

COC(CCCCC=1C[C@@H]2[C@H]([C@@H](C[C@H]2C1)O)\C=C\[C@H](CCCCC)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 50mg/kg (50mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 29, Pg. 2961, 1995.
mouse LD50 intravenous 174mg/kg (174mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 29, Pg. 2961, 1995.
rat LD50 intravenous 56500ug/kg (56.5mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 29, Pg. 2961, 1995.