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Substance Name: N(6)-((dimethylamino)methylene)mitomycin C
RN: 88949-01-3
InChIKey: WZMFNIVNLYRDDE-ZCMHTCKSSA-N

Note

  • Mitomycin C analog.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H23-N5-O5

Molecular Weight

  • 389.4097
 
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Names and Synonyms

Name of Substance

  • N(6)-((dimethylamino)methylene)mitomycin C

Synonyms

  • 7-N-(Dimethylaminomethylene)mitomycin C
  • BMY-25282

Systematic Names

  • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-(((dimethylamino)methylene)amino)-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
  • Methanimidamide, N'-(8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)-N,N-dimethyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-

Registry Numbers

CAS Registry Number

  • 88949-01-3

System Generated Number

  • 0088949013

Structure Descriptors

InChI

1S/C18H23N5O5/c1-8-12(20-7-22(2)3)15(25)11-9(6-28-17(19)26)18(27-4)16-10(21-16)5-23(18)13(11)14(8)24/h7,9-10,16,21H,5-6H2,1-4H3,(H2,19,26)/b20-7+/t9-,10+,16+,18-/m1/s1

InChIKey

WZMFNIVNLYRDDE-ZCMHTCKSSA-N

Smiles

CO[C@]12[C@H]3N[C@H]3CN1C4=C([C@H]2COC(=O)N)C(=O)C(=C(C)C4=O)\N=C\N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2100ug/kg (2.1mg/kg)   Cancer Research. Vol. 45, Pg. 6475, 1985.
mouse LD50 intravenous 1400ug/kg (1.4mg/kg)   Cancer Research. Vol. 45, Pg. 6475, 1985.
rat LDLo intravenous 250ug/kg (0.25mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Fundamental and Applied Toxicology. Vol. 9, Pg. 90, 1987.