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Substance Name: Edaravone [USAN:INN]
RN: 89-25-8
UNII: S798V6YJRP
InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N

Note

  • Free radical scavenger; has strong antiedema activity.

Molecular Formula

  • C10-H10-N2-O

Molecular Weight

  • 174.202
 

Classification Codes

  • Antioxidants
  • Drug / Therapeutic Agent
  • Free Radical Scavengers
  • Mutation Data
  • Neuroprotective
  • Reproductive Effect
  • Skin / Eye Irritant
  • Suppression of Progression of Amyotrophic Lateral Sclerosis (ALS)
  • Tumor Data

Names and Synonyms

Name of Substance

  • 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • Edaravone [USAN:INN]
  • Phenyl methyl pyrazolone
  • Phenylmethylpyrazolone

Synonyms

  • 1-Fenyl-3-methyl-2-pyrazolin-5-on
  • 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]
  • 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
  • 1-Phenyl-3-methyl-5-pyrazolone
  • 1-Phenyl-3-methylpyrazolone
  • 1-Phenyl-3-methylpyrazolone-5
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one
  • 3-Methyl-1-phenyl-5-pyrazolone
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • 5-Pyrazolone, 3-methyl-1-phenyl-
  • AI3-03557
  • BRN 0609575
  • C.I. Developer 1
  • CCRIS 512
  • CI Developer 1
  • Developer Z
  • EC 201-891-0
  • Edaravone
  • EINECS 201-891-0
  • HSDB 4102
  • MCI-186
  • Methylphenylpyrazolone
  • NCI-C03952
  • Norantipyrine
  • Norphenazone
  • NSC 12
  • Phenylmethylpyrazolone
  • Radicava
  • Radicut
  • UNII-S798V6YJRP

Systematic Names

  • 1-Phenyl-3-methyl-5-pyrazolone
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3-Methyl-1-phenyl-5-pyrazolone
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-

Superlist Names

  • 1-Phenyl-3-methyl-5-pyrazolone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one

Registry Numbers

CAS Registry Number

  • 89-25-8

FDA UNII

  • S798V6YJRP

Other Registry Numbers

  • 115566-83-1
  • 12235-58-4
  • 206195-95-1
  • 52224-17-6
  • 62495-97-0
  • 72134-66-8

System Generated Number

  • 0000089258

Structure Descriptors

InChI

1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChIKey

QELUYTUMUWHWMC-UHFFFAOYSA-N

Smiles

CC1=NN(C(=O)C1)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 600mg/kg (600mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: ATAXIA

BLOOD: CHANGES IN SPLEEN
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 intraperitoneal 2012mg/kg (2012mg/kg)   Russian Pharmacology and Toxicology Vol. 36, Pg. 27, 1973.
mouse LD50 intravenous 588mg/kg (588mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 oral 1683mg/kg (1683mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 subcutaneous 691mg/kg (691mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 intravenous 631mg/kg (631mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 oral 1915mg/kg (1915mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 subcutaneous 1101mg/kg (1101mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 129 deg C   EXP
log P (octanol-water) 2.560 (none)   EST
Atmospheric OH Rate Constant 1.31E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.