|
|
|
Substance Name: Edaravone [USAN:INN]
RN: 89-25-8
UNII: S798V6YJRP
InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N
Note
- Free radical scavenger; has strong antiedema activity.
Molecular Formula
- C10-H10-N2-O
Molecular Weight
- 174.202
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antioxidants
- Drug / Therapeutic Agent
- Free Radical Scavengers
- Mutation Data
- Neuroprotective
- Reproductive Effect
- Skin / Eye Irritant
- Suppression of Progression of Amyotrophic Lateral Sclerosis (ALS)
- Tumor Data
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- Edaravone [USAN:INN]
- Phenyl methyl pyrazolone
- Phenylmethylpyrazolone
Synonyms
- 1-Fenyl-3-methyl-2-pyrazolin-5-on
- 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]
- 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
- 1-Phenyl-3-methyl-5-pyrazolone
- 1-Phenyl-3-methylpyrazolone
- 1-Phenyl-3-methylpyrazolone-5
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3-Methyl-1-phenyl-5-pyrazolone
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- 5-Pyrazolone, 3-methyl-1-phenyl-
- AI3-03557
- BRN 0609575
- C.I. Developer 1
- CCRIS 512
- CI Developer 1
- Developer Z
- EC 201-891-0
- Edaravone
- EINECS 201-891-0
- HSDB 4102
- MCI-186
- Methylphenylpyrazolone
- NCI-C03952
- Norantipyrine
- Norphenazone
- NSC 12
- Phenylmethylpyrazolone
- Radicava
- Radicut
- UNII-S798V6YJRP
Systematic Names
- 1-Phenyl-3-methyl-5-pyrazolone
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-5-pyrazolone
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
Superlist Names
- 1-Phenyl-3-methyl-5-pyrazolone
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
Registry Numbers
CAS Registry Number
- 89-25-8
FDA UNII
- S798V6YJRP
Other Registry Numbers
- 115566-83-1
- 12235-58-4
- 206195-95-1
- 52224-17-6
- 62495-97-0
- 72134-66-8
System Generated Number
- 0000089258
Structure Descriptors
InChI
1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-NSmiles
CC1=NN(C(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 600mg/kg (600mg/kg) | LIVER: OTHER CHANGES BEHAVIORAL: ATAXIA BLOOD: CHANGES IN SPLEEN | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | intraperitoneal | 2012mg/kg (2012mg/kg) | Russian Pharmacology and Toxicology Vol. 36, Pg. 27, 1973. | |
| mouse | LD50 | intravenous | 588mg/kg (588mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | oral | 1683mg/kg (1683mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | subcutaneous | 691mg/kg (691mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | intravenous | 631mg/kg (631mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | oral | 1915mg/kg (1915mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | subcutaneous | 1101mg/kg (1101mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 129 | deg C | EXP | |
| log P (octanol-water) | 2.560 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.31E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.