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Substance Name: Edaravone [USAN:INN]
RN: 89-25-8
UNII: S798V6YJRP
InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N
Note
- Free radical scavenger; has strong antiedema activity.
Molecular Formula
- C10-H10-N2-O
Molecular Weight
- 174.202
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antioxidants
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Free Radical Scavengers
- Mutation Data
- Neuroprotective
- Neuroprotective Agents
- Protective Agents
- Reproductive Effect
- Skin / Eye Irritant
- Suppression of Progression of Amyotrophic Lateral Sclerosis (ALS)
- Tumor Data
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Links to Resources
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- Edaravone [USAN:INN]
- Phenyl methyl pyrazolone
- Phenylmethylpyrazolone
MeSH Heading
- Edaravone
Synonyms
- 1-Fenyl-3-methyl-2-pyrazolin-5-on
- 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]
- 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
- 1-Phenyl-3-methyl-5-pyrazolone
- 1-Phenyl-3-methylpyrazolone
- 1-Phenyl-3-methylpyrazolone-5
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3-Methyl-1-phenyl-5-pyrazolone
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- 5-Pyrazolone, 3-methyl-1-phenyl-
- AI3-03557
- BRN 0609575
- C.I. Developer 1
- CCRIS 512
- CI Developer 1
- Developer Z
- EC 201-891-0
- Edaravone
- EINECS 201-891-0
- HSDB 4102
- MCI-186
- Methylphenylpyrazolone
- NCI-C03952
- Norantipyrine
- Norphenazone
- NSC 12
- Phenylmethylpyrazolone
- Radicava
- Radicut
- UNII-S798V6YJRP
Systematic Names
- 1-Phenyl-3-methyl-5-pyrazolone
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-5-pyrazolone
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
Superlist Names
- 1-Phenyl-3-methyl-5-pyrazolone
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
Registry Numbers
CAS Registry Number
- 89-25-8
FDA UNII
- S798V6YJRP
Other Registry Numbers
- 115566-83-1
- 12235-58-4
- 206195-95-1
- 52224-17-6
- 62495-97-0
- 72134-66-8
System Generated Number
- 0000089258
Structure Descriptors
InChI
1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-NSmiles
CC1=NN(C(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 600mg/kg (600mg/kg) | BEHAVIORAL: ATAXIA LIVER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | intraperitoneal | 2012mg/kg (2012mg/kg) | Russian Pharmacology and Toxicology Vol. 36, Pg. 27, 1973. | |
| mouse | LD50 | intravenous | 588mg/kg (588mg/kg) | LIVER: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | oral | 1683mg/kg (1683mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| mouse | LD50 | subcutaneous | 691mg/kg (691mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | intravenous | 631mg/kg (631mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | oral | 1915mg/kg (1915mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
| rat | LD50 | subcutaneous | 1101mg/kg (1101mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 129 | deg C | EXP | |
| log P (octanol-water) | 2.560 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.31E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.