Important Announcement

X

ChemIDplus is moving to PubChem in December 2022.
Please see the NLM Technical Bulletin article for more information.

Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: Edaravone [USAN:INN]
RN: 89-25-8
UNII: S798V6YJRP
InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N

Note

  • An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.

Molecular Formula

  • C10-H10-N2-O

Molecular Weight

  • 174.202
 

Classification Codes

  • Antioxidants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Free Radical Scavengers
  • Mutation Data
  • Neuroprotective
  • Neuroprotective Agents
  • Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant
  • Suppression of Progression of Amyotrophic Lateral Sclerosis (ALS)
  • Tumor Data
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • Edaravone [USAN:INN]
  • Phenyl methyl pyrazolone
  • Phenylmethylpyrazolone

MeSH Heading

  • Edaravone

Synonyms

  • 1-Fenyl-3-methyl-2-pyrazolin-5-on
  • 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]
  • 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
  • 1-Phenyl-3-methyl-5-pyrazolone
  • 1-Phenyl-3-methylpyrazolone
  • 1-Phenyl-3-methylpyrazolone-5
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one
  • 3-Methyl-1-phenyl-5-pyrazolone
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • 5-Pyrazolone, 3-methyl-1-phenyl-
  • AI3-03557
  • BRN 0609575
  • C.I. Developer 1
  • CCRIS 512
  • CI Developer 1
  • Developer Z
  • EC 201-891-0
  • Edaravone
  • EINECS 201-891-0
  • HSDB 4102
  • MCI-186
  • Methylphenylpyrazolone
  • NCI-C03952
  • Norantipyrine
  • Norphenazone
  • NSC 12
  • Phenylmethylpyrazolone
  • Radicava
  • Radicut
  • UNII-S798V6YJRP

Systematic Names

  • 1-Phenyl-3-methyl-5-pyrazolone
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3-Methyl-1-phenyl-5-pyrazolone
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-

Superlist Names

  • 1-Phenyl-3-methyl-5-pyrazolone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one

Registry Numbers

CAS Registry Number

  • 89-25-8

FDA UNII

  • S798V6YJRP

Other Registry Numbers

  • 115566-83-1
  • 12235-58-4
  • 206195-95-1
  • 52224-17-6
  • 62495-97-0
  • 72134-66-8

System Generated Number

  • 0000089258

Structure Descriptors

InChI

InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChIKey

QELUYTUMUWHWMC-UHFFFAOYSA-N

Smiles

CC1=NN(C(=O)C1)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 600mg/kg (600mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: ATAXIA

BLOOD: CHANGES IN SPLEEN		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 intraperitoneal 2012mg/kg (2012mg/kg)   Russian Pharmacology and Toxicology Vol. 36, Pg. 27, 1973.
mouse LD50 intravenous 588mg/kg (588mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 oral 1683mg/kg (1683mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
mouse LD50 subcutaneous 691mg/kg (691mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 intravenous 631mg/kg (631mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 oral 1915mg/kg (1915mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: OTHER CHANGES		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,
rat LD50 subcutaneous 1101mg/kg (1101mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 129 deg C   EXP
log P (octanol-water) 2.560 (none)   EST
Atmospheric OH Rate Constant 1.31E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.