|
|
Substance Name: Edaravone [USAN:INN]
RN: 89-25-8
UNII: S798V6YJRP
InChIKey: QELUYTUMUWHWMC-UHFFFAOYSA-N
Note
- An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE.
Molecular Formula
- C10-H10-N2-O
Molecular Weight
- 174.202
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antioxidants
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Free Radical Scavengers
- Mutation Data
- Neuroprotective
- Neuroprotective Agents
- Protective Agents
- Reproductive Effect
- Skin / Eye Irritant
- Suppression of Progression of Amyotrophic Lateral Sclerosis (ALS)
- Tumor Data
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- Edaravone [USAN:INN]
- Phenyl methyl pyrazolone
- Phenylmethylpyrazolone
MeSH Heading
- Edaravone
Synonyms
- 1-Fenyl-3-methyl-2-pyrazolin-5-on
- 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]
- 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
- 1-Phenyl-3-methyl-5-pyrazolone
- 1-Phenyl-3-methylpyrazolone
- 1-Phenyl-3-methylpyrazolone-5
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
- 3-Methyl-1-phenyl-5-pyrazolone
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- 5-Pyrazolone, 3-methyl-1-phenyl-
- AI3-03557
- BRN 0609575
- C.I. Developer 1
- CCRIS 512
- CI Developer 1
- Developer Z
- EC 201-891-0
- Edaravone
- EINECS 201-891-0
- HSDB 4102
- MCI-186
- Methylphenylpyrazolone
- NCI-C03952
- Norantipyrine
- Norphenazone
- NSC 12
- Phenylmethylpyrazolone
- Radicava
- Radicut
- UNII-S798V6YJRP
Systematic Names
- 1-Phenyl-3-methyl-5-pyrazolone
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-Methyl-1-phenyl-5-pyrazolone
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
Superlist Names
- 1-Phenyl-3-methyl-5-pyrazolone
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
Registry Numbers
CAS Registry Number
- 89-25-8
FDA UNII
- S798V6YJRP
Other Registry Numbers
- 115566-83-1
- 12235-58-4
- 206195-95-1
- 52224-17-6
- 62495-97-0
- 72134-66-8
System Generated Number
- 0000089258
Structure Descriptors
InChI
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-NSmiles
CC1=NN(C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 600mg/kg (600mg/kg) | LIVER: OTHER CHANGES BEHAVIORAL: ATAXIA BLOOD: CHANGES IN SPLEEN | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
mouse | LD50 | intraperitoneal | 2012mg/kg (2012mg/kg) | Russian Pharmacology and Toxicology Vol. 36, Pg. 27, 1973. | |
mouse | LD50 | intravenous | 588mg/kg (588mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
mouse | LD50 | oral | 1683mg/kg (1683mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
mouse | LD50 | subcutaneous | 691mg/kg (691mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
rat | LD50 | intravenous | 631mg/kg (631mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
rat | LD50 | oral | 1915mg/kg (1915mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
rat | LD50 | subcutaneous | 1101mg/kg (1101mg/kg) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25(Suppl, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 129 | deg C | EXP | |
log P (octanol-water) | 2.560 | (none) | EST | |
Atmospheric OH Rate Constant | 1.31E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.