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Substance Name: Nortriptyline hydrochloride [USAN:USP:JAN]
RN: 894-71-3
UNII: 00FN6IH15D
InChIKey: SHAYBENGXDALFF-UHFFFAOYSA-N

Note

  • A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.

Molecular Formula

  • C19-H21-N.Cl-H

Molecular Weight

  • 299.8428
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Nortriptyline hydrochloride
  • Nortriptyline hydrochloride [USAN:USP:JAN]

Synonyms

  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, hydrochloride
  • 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine hydrochloride
  • 38489
  • 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene hydrochloride
  • 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene hydrochloride
  • Acetexa
  • Allegron
  • Altilev
  • Ateben hydrochloride
  • Aventyl
  • Aventyl allegron
  • Aventyl hydrochloride
  • Desmethylamitriptyline hydrochloride
  • EINECS 212-973-0
  • Lilly 38489
  • N 7048
  • Noramitriptyline hydrochloride
  • Noritren
  • Nortab hydrochloride
  • Nortrilen
  • Nortriptylin hydrochloride
  • Nortriptyline HCl
  • Nortriptyline hydrochloride
  • Nortriptyline monohydrochloride
  • Norzepine
  • NSC 169453
  • NSC 78248
  • Pamelor
  • Psychostyl
  • Sensival
  • UNII-00FN6IH15D
  • Vividyl

Systematic Names

  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, hydrochloride
  • 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10-11-dihydro-N-methyl-, hydrochloride
  • Nortriptyline hydrochloride

Registry Numbers

CAS Registry Number

  • 894-71-3

FDA UNII

  • 00FN6IH15D

Other Registry Numbers

  • 37025-22-2
  • 8057-32-7

System Generated Number

  • 0000894713

Molecular Formulas

Molecular Formula

  • C19-H21-N.Cl-H

Molecular Formula Fragments

  • C19-H21-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

InChIKey

SHAYBENGXDALFF-UHFFFAOYSA-N

Smiles

Cl.CNCCC=C1c2ccccc2CCc3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intramuscular > 75mg/kg (75mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 152, 1966.
dog LD50 intramuscular > 75mg/kg (75mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 9, Pg. 152, 1966.
guinea pig LDLo intravenous 44mg/kg (44mg/kg) CARDIAC: OTHER CHANGES Therapie. Vol. 20, Pg. 67, 1965.
mouse LD50 intramuscular 170mg/kg (170mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 461, 1971.
mouse LD50 intraperitoneal 71mg/kg (71mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
mouse LD50 intravenous 18700ug/kg (18.7mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
mouse LD50 oral 260mg/kg (260mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
mouse LD50 subcutaneous 145mg/kg (145mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 9, Pg. 152, 1966.
rat LD50 intramuscular 170mg/kg (170mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
rat LD50 intravenous 13mg/kg (13mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
rat LD50 oral 405mg/kg (405mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
rat LD50 subcutaneous 445mg/kg (445mg/kg)   Drugs in Japan Vol. 6, Pg. 568, 1982.
women TDLo oral 33571ug/kg (33.571mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 10, Pg. 553, 1992.
women TDLo oral 67mg/kg (67mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 12, Pg. 452, 1994.