Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Flumatinib mesylate
RN: 895519-91-2
UNII: 95Y8L63NBC
InChIKey: ZSASDYCFROUKTJ-UHFFFAOYSA-N

Note

  • An antineoplastic agent and tyrosine kinase inhibitor.

    NCI: flumatinib mesylate. The orally bioavailable, mesylate salt form of the tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity. Upon administration, flumatinib inhibits the wild-type forms of Bcr-Abl, platelet-derived growth factor receptor (PDGFR) and mast/stem cell growth factor receptor (SCFR; c-Kit) and forms of these proteins with certain point mutations. This results in the inhibition of both Bcr-Abl-, PDGFR- and c-Kit-mediated signal transduction pathways, and the proliferation of tumor cells in which these kinases are overexpressed. Bcr-Abl fusion protein is an abnormal, constitutively active enzyme expressed in Philadelphia chromosome positive chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML). PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. c-kit, a receptor tyrosine kinase mutated and constitutively activated in certain tumors, plays a key role in tumor cell survival, proliferation, and differentiation. (NCI Thesaurus)

Molecular Formula

  • C29-H29-F3-N8-O.C-H4-O3-S

Molecular Weight

  • 658.7027
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Flumatinib mesylate

Synonym

  • UNII-95Y8L63NBC

Registry Numbers

CAS Registry Number

  • 895519-91-2

FDA UNII

  • 95Y8L63NBC

System Generated Number

  • 0895519912

Structure Descriptors

InChI

1S/C29H29F3N8O.CH4O3S/c1-19-26(38-28-34-9-7-25(37-28)21-4-3-8-33-16-21)15-23(17-35-19)36-27(41)20-5-6-22(24(14-20)29(30,31)32)18-40-12-10-39(2)11-13-40;1-5(2,3)4/h3-9,14-17H,10-13,18H2,1-2H3,(H,36,41)(H,34,37,38);1H3,(H,2,3,4)

InChIKey

ZSASDYCFROUKTJ-UHFFFAOYSA-N

Smiles

Cc1c(cc(cn1)NC(=O)c2ccc(c(c2)C(F)(F)F)CN3CCN(CC3)C)Nc4nccc(n4)c5cccnc5.CS(=O)(=O)O