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Substance Name: Toremifene [INN:BAN]
RN: 89778-26-7
UNII: 7NFE54O27T
InChIKey: XFCLJVABOIYOMF-QPLCGJKRSA-N

Note

  • A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.

Molecular Formula

  • C26-H28-Cl-N-O

Molecular Weight

  • 405.966
 

Classification Codes

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Bone Density Conservation Agents
  • Drug / Therapeutic Agent
  • Estrogen Receptor Modulators
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Mutation Data
  • Reproductive Effect
  • Selective Estrogen Receptor Modulators
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Name of Substance

  • Toremifene
  • Toremifene [INN:BAN]

MeSH Heading

  • Toremifene

Synonyms

  • (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
  • 2-(para-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine (IUPAC)
  • Acapodene
  • CCRIS 8745
  • Farestone
  • GTx 006
  • Toremifene
  • Toremifeno
  • Toremifeno [Spanish]
  • Toremifenum
  • Toremifenum [Latin]
  • UNII-7NFE54O27T
  • Z-Toremifene

Systematic Names

  • Ethanamine, 2-(4-((1Z)-4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-
  • Ethanamine, 2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-

Superlist Name

  • Toremifene

Registry Numbers

CAS Registry Number

  • 89778-26-7

FDA UNII

  • 7NFE54O27T

Other Registry Number

  • 98644-21-4

Related Registry Number

  • 89778-27-8 (citrate (1:1))

System Generated Number

  • 0089778267

Structure Descriptors

InChI

1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25-

InChIKey

XFCLJVABOIYOMF-QPLCGJKRSA-N

Smiles

C(=C(/c1ccccc1)CCCl)(\c1ccc(OCCN(C)C)cc1)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 1700mg/kg (1700mg/kg)   Progress in Cancer Research and Therapy. Vol. 35, Pg. 374, 1988.
rat LD50 oral 1700mg/kg (1700mg/kg) GASTROINTESTINAL: OTHER CHANGES Progress in Cancer Research and Therapy. Vol. 35, Pg. 374, 1988.