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Substance Name: Tazobactam [USAN:USP:INN:BAN]
RN: 89786-04-9
UNII: SE10G96M8W
InChIKey: LPQZKKCYTLCDGQ-WEDXCCLWSA-N
Note
- A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria.
Molecular Formula
- C10-H12-N4-O5-S
Molecular Weight
- 300.2938
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- beta-Lactamase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Inhibitor (beta-Lactamase)
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Tazobactam
- Tazobactam [USAN:USP:INN:BAN]
MeSH Heading
- Tazobactam
Synonyms
- (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 4,4-dioxide
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S-(2alpha,3beta,5alpha))-
- BRN 4787943
- CCRIS 2203
- CL 298,741
- Cl 298741
- EC 618-303-7
- NSC 759887
- Tazobactam
- Tazobactamum
- Tazobactamum [INN-Latin]
- UNII-SE10G96M8W
- YTR 830H
- YTR-830H
Systematic Names
- (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S-(2alpha,3beta,5alpha))-
- YTR 830 H
Mixture Name
- Zosyn
Registry Numbers
CAS Registry Number
- 89786-04-9
FDA UNII
- SE10G96M8W
System Generated Number
- 0089786049
Structure Descriptors
InChI
InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1InChIKey
LPQZKKCYTLCDGQ-WEDXCCLWSA-NSmiles
C[C@]1(Cn2ccnn2)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | > 5gm/kg (5000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: HEMATURIA | Journal of Toxicological Sciences. Vol. 19(Suppl, |
mouse | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Toxicological Sciences. Vol. 19(Suppl, |
mouse | LD50 | intravenous | > 5gm/kg (5000mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Toxicological Sciences. Vol. 19(Suppl, |
mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Toxicological Sciences. Vol. 19(Suppl, |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Toxicological Sciences. Vol. 19(Suppl, |
rat | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Toxicological Sciences. Vol. 19(Suppl, |
rat | LD50 | intravenous | > 5gm/kg (5000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Journal of Toxicological Sciences. Vol. 19(Suppl, |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Journal of Toxicological Sciences. Vol. 19(Suppl, |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Journal of Toxicological Sciences. Vol. 19(Suppl, |