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Substance Name: Tozasertib lactate [USAN]
RN: 899827-04-4
UNII: CN8EF9N084
InChIKey: MHFUWOIXNMZFIW-WNQIDUERSA-N

Note

  • A potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth.

    NCI: The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis. (NCI Thesaurus)

Molecular Formula

  • C23-H28-N8-O-S.x(C3-H6-O3)

Molecular Weight

  • 554.6726
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Tozasertib lactate [USAN]

Synonyms

  • MK-0457
  • N-(4-((4-(4-Methylpiperazin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide (2S)-2-hydroxypropanoate
  • Tozasertib lactate
  • UNII-CN8EF9N084
  • VX-680

Systematic Name

  • Propanoic acid, 2-hydroxy-, (2S)-, compd. with N-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)cyclopropanecarboxamide

Registry Numbers

CAS Registry Number

  • 899827-04-4

FDA UNII

  • CN8EF9N084

System Generated Number

  • 0899827044

Structure Descriptors

InChI

1S/C23H28N8OS.C3H6O3/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16;1-2(4)3(5)6/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29);2,4H,1H3,(H,5,6)/t;2-/m.0/s1

InChIKey

MHFUWOIXNMZFIW-WNQIDUERSA-N