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Substance Name: Hymecromone [USAN:INN:BAN:JAN]
RN: 90-33-5
UNII: 3T5NG4Q468
InChIKey: HSHNITRMYYLLCV-UHFFFAOYSA-N

Note

  • A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.

Molecular Formula

  • C10-H8-O3

Molecular Weight

  • 176.1702
 

Classification Codes

  • Choleretic
  • Drug / Therapeutic Agent
  • Indicators and Reagents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Hymecromone
  • Hymecromone [USAN:INN:BAN:JAN]

MeSH Heading

  • Hymecromone

Synonyms

  • 2H-1-Benzopyran, 7-hydroxy-4-methyl-2-oxo-
  • 2H-1-Benzopyren-2-one, 7-hydroxy-4-methyl-
  • 4-Methyl-7-hydroxycoumarin
  • 4-Methylumbelliferon
  • 4-Methylumbelliferon [Czech]
  • 4-Methylumbelliferone
  • 5-18-01-00439 (Beilstein Handbook Reference)
  • 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran
  • 7-Hydroxy-4-methylcoumarin
  • AI3-08085
  • beta-Methylumbelliferone
  • Bilcolic
  • Bilicante
  • BRN 0142217
  • Cantabilin
  • Cantabiline
  • CCRIS 5926
  • Cholestil
  • Cholonerton
  • Coumarin 4
  • Crodimon
  • Cumarote-C
  • EINECS 201-986-7
  • Eurogale
  • Himecromona
  • Himecromona [INN-Spanish]
  • Hymecromon
  • Hymecromone
  • Hymecromonum
  • Hymecromonum [INN-Latin]
  • Imecromone
  • Imecromone [DCIT]
  • LM 94
  • LM-94
  • Medilla
  • Mendiaxon
  • Methylumbelliferone
  • NSC 19026
  • NSC 9408
  • Omega 127
  • Pilot 447
  • Resocyanine
  • Unichol
  • UNII-3T5NG4Q468

Systematic Names

  • 2H-1-Benzopyran-2-one, 7-hydroxy-4-methyl-
  • beta-Methylumbelliferone
  • Coumarin, 7-hydroxy-4-methyl-
  • Hymecromone

Registry Numbers

CAS Registry Number

  • 90-33-5

FDA UNII

  • 3T5NG4Q468

Other Registry Number

  • 56275-29-7

System Generated Number

  • 0000090335

Structure Descriptors

InChI

1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3

InChIKey

HSHNITRMYYLLCV-UHFFFAOYSA-N

Smiles

c12c(c(cc(o1)=O)C)ccc(c2)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1250mg/kg (1250mg/kg)   Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 555, 1958.
mouse LD50 oral 2850mg/kg (2850mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1619, 1971.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1619, 1971.
rat LD50 intraperitoneal 2550mg/kg (2550mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1619, 1971.
rat LD50 oral 3850mg/kg (3850mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1619, 1971.
rat LD50 subcutaneous 7200mg/kg (7200mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1619, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 195.5 deg C   EXP
log P (octanol-water) 1.9 (none)   EXP
Water Solubility 5210 mg/L 25 EST
Vapor Pressure 7.24E-06 mm Hg 25 EST
Henry's Law Constant 1.13E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.30E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.