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Substance Name: Pseudoephedrine [INN:BAN]
RN: 90-82-4
UNII: 7CUC9DDI9F
InChIKey: KWGRBVOPPLSCSI-WCBMZHEXSA-N
Note
- A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
Molecular Formula
- C10-H15-N-O
Molecular Weight
- 165.2345
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Asthmatic Agents
- Autonomic Agents
- Bronchodilator Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Nasal Decongestants
- Peripheral Nervous System Agents
- Respiratory System Agents
- Vasoconstrictor Agents
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Names and Synonyms
Name of Substance
- (+)-Pseudoephedrine
- Pseudoephedrine [INN:BAN]
MeSH Heading
- Pseudoephedrine
Synonyms
- (+)-(1S,2S)-Pseudoephedrine
- (+)-Pseudoephedrine
- (+)-psi-Ephedrine
- (+)-threo-Ephedrine
- (1S,2S)-(+)-Pseudoephedrine
- (1S,2S)-Pseudoephedrine
- alpha-(1-(Methylamino)ethyl)benzyl alcohol
- Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (S-(R*,R*))-
- Besan
- d-Isoephedrine
- D-Pseudoephedrine
- d-psi-2-Methylamino-1-phenyl-1-propanol
- d-psi-Ephedrine
- EC 202-018-6
- EINECS 202-018-6
- HSDB 3177
- Isoephedrine
- L(+)-psi-Ephedrine
- L-(+)-Pseudoephedrine
- Pseudoefedrina
- Pseudoefedrina [INN-Spanish]
- Pseudoephedrine
- Pseudoephedrine (D)
- Pseudoephedrine, (+)-
- Pseudoephedrinum
- Pseudoephedrinum [INN-Latin]
- Psi-ephedrin
- psi-Ephedrine
- psi-Ephedrine, (+)-
- Sudafed
- trans-Ephedrine
- UNII-7CUC9DDI9F
Systematic Names
- Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)-
- Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaS)-
- Pseudoephedrine
- Pseudoephedrine, L-(+)-
Registry Numbers
CAS Registry Number
- 90-82-4
FDA UNII
- 7CUC9DDI9F
Other Registry Numbers
- 304-87-0
- 30987-59-8
- 37577-31-4
System Generated Number
- 0000090824
Structure Descriptors
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1InChIKey
KWGRBVOPPLSCSI-WCBMZHEXSA-NSmiles
CN[C@@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 20mg/kg/12H-I (20mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | American Journal of Emergency Medicine. Vol. 15, Pg. 521, 1997. |
dog | LDLo | intravenous | 125mg/kg (125mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 225, 1973. | |
man | TDLo | oral | 12mg/kg (12mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | American Journal of Emergency Medicine. Vol. 4, Pg. 141, 1986. |
man | TDLo | oral | 64mg/kg (64mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: TREMOR | Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 109, 1992. |
mouse | LD50 | intravenous | 88mg/kg (88mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 148, Pg. 158, 1965. |
mouse | LD50 | oral | 500mg/kg (500mg/kg) | Journal of Pharmaceutical Sciences. Vol. 60, Pg. 1523, 1971. | |
rabbit | LDLo | intravenous | 85mg/kg (85mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 225, 1973. | |
rabbit | LDLo | subcutaneous | 400mg/kg (400mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 225, 1973. | |
rat | LD50 | oral | 660mg/kg (660mg/kg) | Journal of Pharmaceutical Sciences. Vol. 60, Pg. 1523, 1971. | |
rat | LDLo | subcutaneous | 650mg/kg (650mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 225, 1973. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 119 | deg C | EXP | |
pKa Dissociation Constant | 10.252 | (none) | 0 | EXP |
log P (octanol-water) | 0.89 | (none) | EXP | |
Water Solubility | 1.06E+05 | mg/L | 25 | EST |
Vapor Pressure | 8.30E-04 | mm Hg | 25 | EST |
Henry's Law Constant | 8.65E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 9.97E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.