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Substance Name: Amfepramone [INN]
RN: 90-84-6
UNII: Q94YYU22B8
InChIKey: XXEPPPIWZFICOJ-UHFFFAOYSA-N

Note

  • A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Molecular Formula

  • C13-H19-N-O

Molecular Weight

  • 205.299
 

Classification Codes

Classification Codes

  • Anti-Obesity Agents
  • Appetite Depressants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data

Superlist Classification Code

  • DEA Schedule IV

Names and Synonyms

Name of Substance

  • Amfepramone [INN]
  • Diethylpropion

MeSH Heading

  • Diethylpropion

Synonyms

  • 1-Phenyl-2-diethylamino-1-propanone
  • 1-Propanone, 2-(diethylamino)-1-phenyl-
  • 2-(Diethylamino)-1-phenyl-1-propanone
  • 2-(Diethylamino)propiophenone
  • 4-14-00-00144 (Beilstein Handbook Reference)
  • Adiposon
  • alpha-Benzoyltriethylamine
  • alpha-Diethylaminopropiophenone
  • Amfepramon
  • Amfepramone
  • Amfepramonum
  • Amfepramonum [INN-Latin]
  • Amphepramon
  • Amphepramone
  • Anfepramona
  • Anfepramona [INN-Spanish]
  • Anorex
  • BRN 2804400
  • Cegramine
  • Danylen
  • Derfon
  • Diethylpropion
  • Diethylpropione
  • Dobesin
  • EINECS 202-019-1
  • Fenyl-(1-diethylaminoethyl)keton
  • Fenyl-(1-diethylaminoethyl)keton [Czech]
  • Frekentine
  • HSDB 3059
  • Magrene
  • Neobes
  • Nopropiophenone
  • Obesitex
  • Propiophenone, 2-(diethylamino)-
  • Silutin
  • Tepanil
  • Tylinal
  • UNII-Q94YYU22B8
  • UR 1423

Systematic Names

  • 1-Propanone, 2-(diethylamino)-1-phenyl-
  • Amfepramone
  • Propiophenone, 2-diethylamino-

Superlist Names

  • DEA No. 1610
  • Diethylpropion

Registry Numbers

CAS Registry Number

  • 90-84-6

FDA UNII

  • Q94YYU22B8

System Generated Number

  • 0000090846

Structure Descriptors

InChI

1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3

InChIKey

XXEPPPIWZFICOJ-UHFFFAOYSA-N

Smiles

c1(C([C@@H](N(CC)CC)C)=O)ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 11mg/kg (11mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Therapie. Vol. 34, Pg. 205, 1979.
mouse LD50 intraperitoneal 24mg/kg (24mg/kg)   Journal de Pharmacologie. Vol. 17, Pg. 37, 1986.
mouse LD50 oral 160mg/kg (160mg/kg)   Therapie. Vol. 20, Pg. 297, 1965.
rat LD50 oral > 400mg/kg (400mg/kg)   Journal of Medicinal Chemistry. Vol. 18, Pg. 177, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.040 (none)   EST
Atmospheric OH Rate Constant 9.95E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.