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Substance Name: Diethylcarbamazine [INN:BAN]
RN: 90-89-1
UNII: V867Q8X3ZD
InChIKey: RCKMWOKWVGPNJF-UHFFFAOYSA-N

Note

  • An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Molecular Formula

  • C10-H21-N3-O

Molecular Weight

  • 199.2959
 

Classification Codes

  • Anthelmintics
  • Anti-Infective Agents
  • Antinematodal Agents
  • Antiparasitic Agents
  • Enzyme Inhibitors
  • Filaricides
  • Human Data
  • Lipoxygenase Inhibitors
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Diethylcarbamazine
  • Diethylcarbamazine [INN:BAN]

MeSH Heading

  • Diethylcarbamazine

Synonyms

  • 4-23-00-00225 (Beilstein Handbook Reference)
  • 84L
  • AI3-19612
  • Bitirazine
  • BRN 0143029
  • Caracide
  • Carbamazine
  • Carbilazine
  • Caricide
  • Cypip
  • Diaethylcarbamazinum
  • Diethylcarbamazine
  • Diethylcarbamazinum
  • Diethylcarbamazinum [INN-Latin]
  • Dietilcarbamazina
  • Dietilcarbamazina [INN-Spanish]
  • Ditrazine Base
  • EC 202-023-3
  • EINECS 202-023-3
  • Ethodryl
  • Hetrazan
  • Loxuran
  • Notezine
  • RP 3799
  • Spatonin
  • UNII-V867Q8X3ZD

Systematic Names

  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-
  • Diethylcarbamazine

Registry Numbers

CAS Registry Number

  • 90-89-1

FDA UNII

  • V867Q8X3ZD

Other Registry Numbers

  • 12672-34-3
  • 8028-18-0

Related Registry Numbers

  • 1642-54-2 (citrate (1:1))
  • 5348-97-0 (mono-hydrochloride)

System Generated Number

  • 0000090891

Structure Descriptors

InChI

1S/C10H21N3O/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13/h4-9H2,1-3H3

InChIKey

RCKMWOKWVGPNJF-UHFFFAOYSA-N

Smiles

CCN(CC)C(=O)N1CCN(C)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 240mg/kg (240mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 22, Pg. 306, 1970.
women TDLo oral 7300mg/kg/1Y- (7300mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 291, Pg. 632, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 48 deg C   EXP
log P (octanol-water) 0.370 (none)   EST
Atmospheric OH Rate Constant 1.08E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.