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Substance Name: Podophyllum resin
RN: 9000-55-9
UNII: 16902YVY2B
InChIKey: YJGVMLPVUAXIQN-XVVDYKMHSA-N

Note

  • Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.

Molecular Weight

  • 414.4078
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Caustic
  • Caustics
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Keratolytic Agents
  • Natural Product
  • Noxae
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Podophyllin
  • Podophyllum
  • Podophyllum resin

MeSH Heading

  • Podophyllin

Synonyms

  • CCRIS 4391
  • EINECS 232-546-2
  • Podofillina
  • Podofillina [Italian]
  • Podophyllin
  • Podophyllum
  • Podophyllum resin
  • UNII-16902YVY2B

Systematic Names

  • Podophyllin
  • Podophyllum (resin)

Registry Numbers

CAS Registry Number

  • 9000-55-9

FDA UNII

  • 16902YVY2B

Other Registry Numbers

  • 8050-60-0
  • 8061-07-2
  • 8063-20-5

System Generated Number

  • 0009000559

Structure Descriptors

InChI

1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1

InChIKey

YJGVMLPVUAXIQN-XVVDYKMHSA-N

Smiles

COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo unreported 120mg/kg (120mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
man LDLo oral 157mg/kg (157mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Southern Medical Journal. Vol. 75, Pg. 1269, 1982.
man TDLo oral 1333mg/kg (1333mg/kg) BEHAVIORAL: COMA Human Toxicology. Vol. 1, Pg. 373, 1982.
mouse LD50 oral 68mg/kg (68mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
mouse LD50 subcutaneous 58mg/kg (58mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
rat LD50 intraperitoneal 15mg/kg (15mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 113, Pg. 124, 1963.
rat LD50 parenteral 25mg/kg (25mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 68, 1950.
rat LD50 subcutaneous 18mg/kg (18mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: EXCITEMENT
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
women LDLo oral 6mg/kg (6mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 482, 1969.
women TDLo oral 80mg/kg (80mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
Clinical Toxicology. Vol. 18, Pg. 973, 1981.