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Substance Name: Bromelains [USAN:INN:BAN]
RN: 9001-00-7

Note

  • Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Anti-Inflammatory
  • Drug / Therapeutic Agent
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources

Names and Synonyms

Name of Substance

  • Bromelains
  • Bromelains [USAN:INN:BAN]

MeSH Heading

  • Bromelains

Synonyms

  • Ananase
  • Bromelain
  • Bromelain juice
  • Bromelain protease
  • Bromelaina
  • Bromelaina [INN-Latin]
  • Bromelaines
  • Bromelaines [INN-French]
  • Bromelains
  • Bromelin
  • E.C. 3.4.4.24
  • EINECS 232-572-4
  • Extranase
  • HSDB 7202
  • Inflamen
  • Paimerin
  • Penlase
  • Pineapple protease
  • Pineapple protease and milk clotting enzyme
  • Plant protease concentrate
  • Proteolis
  • Resolvit
  • Rogorin
  • Traumanase
  • UNII-F0ZCA6O9QT
  • UNII-U182GP2CF3

Systematic Names

  • Bromelain
  • Bromelain, fruit
  • Bromelain, juice

Superlist Name

  • Bromelain

Registry Numbers

CAS Registry Number

  • 9001-00-7

FDA UNIIs

  • F0ZCA6O9QT
  • U182GP2CF3

Other Registry Numbers

  • 37187-68-1
  • 9015-70-7

System Generated Number

  • 0009001007

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 36700ug/kg (36.7mg/kg) BEHAVIORAL: IRRITABILITY Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 166, 1963.
mouse LD50 intravenous 30mg/kg (30mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 166, 1963.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 166, 1963.
rabbit LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 166, 1963.
rat LD50 intraperitoneal 85200ug/kg (85.2mg/kg) BEHAVIORAL: IRRITABILITY Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 166, 1963.
rat LD50 oral > 10gm/kg (10000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 166, 1963.