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Substance Name: Chymopapain [USAN:INN:BAN]
RN: 9001-09-6
UNII: 1UK146T40N

Note

  • A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme (Proteolytic)
  • Natural Product

Names and Synonyms

Name of Substance

  • Chymopapain
  • Chymopapain [USAN:INN:BAN]

MeSH Heading

  • Chymopapain

Synonyms

  • BAX 1526
  • Chymodiactin
  • Chymopapain
  • Chymopapaine
  • Chymopapaine [INN-French]
  • Chymopapainum
  • Chymopapainum [INN-Latin]
  • Discase
  • E.C.3.4.22.6
  • E.C.3.4.4.11
  • EINECS 232-580-8
  • NSC-107079
  • Quimopapaina
  • Quimopapaina [INN-Spanish]
  • UNII-1UK146T40N

Systematic Name

  • Chymopapain

Registry Numbers

CAS Registry Number

  • 9001-09-6

FDA UNII

  • 1UK146T40N

System Generated Number

  • 0009001096

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intraspinal > 339ug/kg (0.339mg/kg) SPINAL CORD: OTHER DEGENERATIVE CHANGES Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 1963, 1993.
mouse LD50 intravenous 42300ug/kg (42.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 1963, 1993.
rat LD50 intravenous 36100ug/kg (36.1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 1963, 1993.