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Substance Name: Chymopapain [USAN:INN:BAN]
RN: 9001-09-6
UNII: 1UK146T40N

Note

  • A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.

Molecular Weight

  • 23648.6792
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme (Proteolytic)
  • Natural Product

Names and Synonyms

Name of Substance

  • Chymopapain
  • Chymopapain [USAN:INN:BAN]

MeSH Heading

  • Chymopapain

Synonyms

  • BAX 1526
  • Chymodiactin
  • Chymopapain
  • Chymopapaine
  • Chymopapaine [INN-French]
  • Chymopapainum
  • Chymopapainum [INN-Latin]
  • Discase
  • E.C.3.4.22.6
  • E.C.3.4.4.11
  • EINECS 232-580-8
  • NSC-107079
  • Quimopapaina
  • Quimopapaina [INN-Spanish]
  • UNII-1UK146T40N

Systematic Name

  • Chymopapain

Registry Numbers

CAS Registry Number

  • 9001-09-6

FDA UNII

  • 1UK146T40N

System Generated Number

  • 0009001096

Structure Descriptors

Smiles

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N5CCC[C@H]5C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H]6CSSC[C@@H]7NC(=O)CNC(=O)[C@H](Cc8ccc(O)cc8)NC(=O)[C@H](CO)NC(=O)[C@H](Cc9cnc[nH]9)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]%10CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc%11ccc(O)cc%11)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc%12ccc(O)cc%12)NC(=O)[C@@H]%13CCCN%13C(=O)[C@H](Cc%14ccc(O)cc%14)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc%15cnc[nH]%15)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc%16ccc(O)cc%16)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc%17ccc(O)cc%17)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC7=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N%18CCC[C@H]%18C(=O)NCC(=O)N%19CCC[C@H]%19C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc%20ccc(O)cc%20)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N%21CCC[C@H]%21C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)CNC6=O)C(=O)N[C@@H](Cc%22c[nH]c%23ccccc%22%23)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc%24ccccc%24)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N%10)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%25ccccc%25)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N%26CCC[C@H]%26C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N%27CCC[C@H]%27C(=O)N[C@@H](Cc%28ccccc%28)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc%29ccc(O)cc%29)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc%30ccccc%30)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N%31CCC[C@H]%31C(=O)N[C@H]%32CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc%33ccc(O)cc%33)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](Cc%34c[nH]c%35ccccc%34%35)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]%36CCCN%36C(=O)CNC(=O)[C@H](Cc%37c[nH]c%38ccccc%37%38)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc%39ccc(O)cc%39)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc%40ccc(O)cc%40)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc%41cnc[nH]%41)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CNC%32=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc%42ccc(O)cc%42)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%43ccc(O)cc%43)C(=O)N[C@@H](Cc%44ccc(O)cc%44)C(=O)N%45CCC[C@H]%45C(=O)N[C@@H](Cc%46ccccc%46)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](Cc%47ccccc%47)C(=O)N[C@@H](C)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intraspinal > 339ug/kg (0.339mg/kg) SPINAL CORD: OTHER DEGENERATIVE CHANGES Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 1963, 1993.
mouse LD50 intravenous 42300ug/kg (42.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 1963, 1993.
rat LD50 intravenous 36100ug/kg (36.1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 1963, 1993.