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Substance Name: Collagenase clostridium histolyticum [USAN]
RN: 9001-12-1


  • A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.
  • A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
  • A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC
  • Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.

Molecular Formula

  • Unspecified

Classification Code

  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Results Name

  • Collagenase clostridium histolyticum [USAN]

Name of Substance

  • Collagenase clostridium histolyticum
  • Collagenase clostridium histolyticum [USAN]

MeSH Heading

  • Collagenase


  • Biozyme C salbe
  • CCH
  • Clostridial collagenase
  • Clostridiopeptidase A
  • Clostridium histolyticum collagenase
  • Collagen protease
  • Collagenase
  • Collagenase A
  • Collagenase clostridium histolyticum
  • EINECS 232-582-9
  • Euphaulysin
  • Iruxol
  • Liberase
  • Matrix metalloproteinase-1
  • Matrix metalloproteinase-8
  • MMP-1
  • MMP-8
  • Morikraz
  • Santyl
  • Santyl salbe
  • Soycollagestin
  • Ulcerase salbe
  • UNII-9X7O8V25IT
  • Xiaflex
  • Xiapex

Systematic Name

  • Collagenase

Registry Numbers

CAS Registry Number

  • 9001-12-1


  • 9X7O8V25IT

Other Registry Numbers

  • 106043-70-3
  • 308064-64-4
  • 39433-96-0

System Generated Number

  • 0009001121