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Substance Name: Hemocoagulase [JAN]
RN: 9001-13-2

Note

  • Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.
 

Classification Codes

Classification Codes

  • Coagulants
  • Hematologic Agents
  • Reproductive Effect

Superlist Classification Code

  • TWA (10 ppm), resp fraction >5% SiO2; (2.4 ppm), resp fraction <5% SiO2;
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Links to Resources

Names and Synonyms

Name of Substance

  • Hemocoagulase [JAN]
  • Plasmocoagulase

MeSH Heading

  • Coagulase

Synonyms

  • EINECS 232-583-4
  • Enzyme obtained from the venom of the viper Bothrops jararca
  • Hemocoagulase
  • Heptocoagulase
  • Peptocoagulase
  • Plasma coagulase
  • Plasmocoagulase
  • Reptilase S
  • RP-093
  • Staphylocoagulase
  • Thrombin coagulase

Systematic Names

  • Coagulase
  • Enzyme obtained from the venom of the viper Bothrops jararca.

Registry Numbers

CAS Registry Number

  • 9001-13-2

System Generated Number

  • 0009001132

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 1260, 1995.
mouse LD50 intravenous 53700uL/kg (53.7mL/kg) BEHAVIORAL: TREMOR Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 15, Pg. 383, 1968.
mouse LD50 subcutaneous 107mL/kg (107mL/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 15, Pg. 383, 1968.
rat LD50 intramuscular > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 1260, 1995.
rat LD50 intravenous 160ku/kg (160000iu/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2304, 1975.
rat LD50 subcutaneous > 1500ku/kg (1500000iu/kg)   Kiso to Rinsho. Clinical Report. Vol. 9, Pg. 2304, 1975.