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Substance Name: Beroctocog alfa [INN]
RN: 9001-27-8
UNII: 5T6B772R4Q

Note

  • Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Coagulants
  • Drug / Therapeutic Agent
  • Hematologic Agents

Names and Synonyms

Name of Substance

  • Beroctocog alfa [INN]
  • Factor VIII

MeSH Heading

  • Factor VIII

Synonyms

  • Actif VIII
  • AHF-HP
  • Alphanate
  • Amofil
  • Amtihaemophilic factor
  • Antihaemophiler faktor A
  • Antihaemophiles globulin
  • Antihemophilic factor human
  • Antihemophilic factor/von willebrand factor complex (human))
  • Beroctocog alfa
  • Biostate
  • Biostate P
  • Blood-coagulation factor VIII
  • EINECS 232-593-9
  • Emoclot
  • Factor VIII
  • Factorate
  • Haemate HS
  • Haemate P
  • Hemate P
  • Hemofil
  • Hemofil M
  • Humafac
  • Human coagulation factor viii/von willebrand factor complex
  • Humate P
  • Humate-P
  • Koate DVI
  • Koate HP
  • Koate-HP
  • Kogenate FS
  • Kovaltry
  • Kryobulin
  • Monarc-M
  • Monoclate-P
  • Nordiocto
  • Octanate
  • Octonativ-M7
  • Optivate
  • Profilate
  • Profilate HP
  • Thromboplastinogen
  • UNII-5T6B772R4Q
  • Wilate
  • Wiloctin

Systematic Names

  • Blood-coagulation factor VIII
  • Blood-coagulation factor VIII, complex

Registry Numbers

CAS Registry Number

  • 9001-27-8

FDA UNII

  • 5T6B772R4Q

Other Registry Numbers

  • 114046-09-2
  • 9035-62-5

System Generated Number

  • 0009001278

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous > 1320units/kg (1320units/kg)   Journal of Toxicology and Environmental Health. Vol. 15, Pg. 801, 1985.
rabbit LD50 intravenous > 860iu/kg (860iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2926, 1993.
rat LD50 intravenous > 1320units/kg (1320units/kg)   Journal of Toxicology and Environmental Health. Vol. 15, Pg. 801, 1985.