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Substance Name: Glucose oxidase [USAN]
RN: 9001-37-0
UNII: 0T8392U5N1

Note

  • An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to D-glucono-1,5-lactone and peroxide. It is a flavoprotein, highly specific for beta-D-glucose. The enzyme is produced by Penicillium notatum and other fungi and has antibacterial activity in the presence of glucose and oxygen. It is used to estimate glucose concentration in blood or urine samples through the formation of colored dyes by the hydrogen peroxide produced in the reaction. (From Enzyme Nomenclature, 1992) EC 1.1.3.4.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
  • Treatment or Prevention of Infections Caused by Bacteria, Fungi Orviruses
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources

Names and Synonyms

Name of Substance

  • Glucose oxidase
  • Glucose oxidase [USAN]
  • Oxidase, glucose

MeSH Heading

  • Glucose oxidase

Synonyms

  • beta-D-Glucose oxidase
  • beta-D-Glucose:quinone oxidoreductase
  • CCRIS 3425
  • Corylophyline
  • Deoxin-1
  • E.C. 1.1.3.4
  • EINECS 232-601-0
  • Glucose aerodehydrogenase
  • Glucose oxidase
  • Glucose oxidase (EC 1.1.3.4) from aspergillus niger
  • GO
  • Microcid
  • Notatin
  • Oxidase, glucose
  • Penatin
  • UNII-0T8392U5N1

Systematic Names

  • Glucose oxidase
  • Oxidase, glucose

Registry Numbers

CAS Registry Number

  • 9001-37-0

FDA UNII

  • 0T8392U5N1

Other Registry Number

  • 9051-05-2

System Generated Number

  • 0009001370

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous > 30mg/kg (30mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: FOOD INTAKE (ANIMAL)
British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 225, 1946.
dog LDLo intravenous > 30mg/kg (30mg/kg) BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: FOOD INTAKE (ANIMAL)
British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 225, 1946.
mammal (species unspecified) LDLo oral > 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN

BEHAVIORAL: FOOD INTAKE (ANIMAL)
British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 225, 1946.
mouse LD50 intraperitoneal 3mg/kg (3mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(2), Pg. 302, 1980.
mouse LD50 intravenous 13mg/kg (13mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BLOOD: CHANGE IN CLOTTING FACTORS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 225, 1946.
mouse LD50 subcutaneous 4500ug/kg (4.5mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(2), Pg. 302, 1980.
rabbit LD50 subcutaneous 7500ug/kg (7.5mg/kg) ENDOCRINE: HYPERGLYCEMIA British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 225, 1946.