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Substance Name: Isocitrate dehydrogenase
RN: 9001-58-5


  • An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC EC

Molecular Formula

  • Unspecified

Classification Code

  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Names and Synonyms

MeSH Heading

  • Isocitrate Dehydrogenase


  • Isocitrate dehydrogenase

Systematic Names

  • Dehydrogenase, isocitrate
  • Isocitrate dehydrogenase

Registry Numbers

CAS Registry Number

  • 9001-58-5

Other Registry Number

  • 9013-84-7

System Generated Number

  • 0009001585