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Substance Name: Rizolipase [INN:DCF]
RN: 9001-62-1

Note

  • An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Enzyme (Digestant Adjunct)
  • Reproductive Effect
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Name of Substance

  • Pancrelipase
  • Rizolipase [INN:DCF]

MeSH Heading

  • Lipase

Synonyms

  • Accelerase
  • Allzyme Lipase
  • Amano N-AP
  • Butyrinase
  • CCRIS 9507
  • Chirazyme L
  • Cotazym
  • Creon
  • E.C.3.1.1.3.
  • EC 232-619-9
  • EINECS 232-619-9
  • Entolase
  • Enzylon PF
  • Fetipase
  • Fluozim G 3Kh
  • Fungal lipase
  • GA 56 (Enzyme)
  • GA-56
  • Glycerol ester hydrolase
  • Ilozyme
  • Ku-zyme HP
  • Lipase
  • Lipase AP
  • Lipase of pancreas
  • Lipase, fungal
  • Lipase, triacylglycerol
  • Lipazin
  • Meito MY 30
  • Pancrease
  • Pancrelipase
  • Pancrelipase lipase
  • Remzyme PL 600
  • Rizolipasa
  • Rizolipasa [INN-Spanish]
  • Rizolipase
  • Rizolipasum
  • Rizolipasum [INN-Latin]
  • Steapsin
  • Takedo 1969-4-9
  • TheraCLEC-Lipase
  • Triacetinase
  • Triacylglycerol hydrolase
  • Triacylglycerol lipase
  • Tributyrase
  • Tributyrin esterase
  • Tributyrinase
  • Triglyceride hydrolase
  • Triglyceride lipase
  • Triolein hydrolase
  • Tween esterase
  • Tween hydrolase
  • Tweenase
  • UNII-8MYC33932O
  • UNII-OCG8G5QG5K
  • Viokase
  • Zymase

Systematic Names

  • Lipase of Rhizopus arrhizus var. Delemar
  • Lipase, triacylglycerol
  • Plant lipase
  • Triacylglycerol lipase

Superlist Names

  • Animal lipase
  • Triacylglycerol lipase

Registry Numbers

CAS Registry Number

  • 9001-62-1

FDA UNIIs

  • 8MYC33932O
  • OCG8G5QG5K

Other Registry Numbers

  • 114558-43-9
  • 114558-45-1
  • 119663-46-6
  • 132823-04-2
  • 135105-44-1
  • 142615-72-3
  • 211049-96-6
  • 211049-97-7
  • 211255-77-5
  • 212955-16-3
  • 9001-70-1
  • 9004-01-7
  • 9014-49-7

System Generated Number

  • 0009001621

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 135mg/kg (135mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.
mouse LD oral > 10400mg/kg (10400mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
mouse LD50 intraperitoneal 395mg/kg (395mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
mouse LD50 intraperitoneal 833mg/kg (833mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.
mouse LD50 intravenous 127mg/kg (127mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.
mouse LD50 subcutaneous 2050mg/kg (2050mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
rabbit LD oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
rat LD oral > 10400mg/kg (10400mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
rat LD subcutaneous > 5gm/kg (5000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
rat LD50 intraperitoneal 630mg/kg (630mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.
rat LD50 intraperitoneal 634mg/kg (634mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.
rat LD50 intravenous 104mg/kg (104mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.