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Substance Name: Papain [USP]
RN: 9001-73-4
UNII: A236A06Y32

Note

  • A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme (Proteolytic)
  • Human Data
  • Natural Product
  • Reproductive Effect
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources

Names and Synonyms

Name of Substance

  • Papain
  • Papain [USP]

MeSH Heading

  • Papain

Synonyms

  • Arbuz
  • Caroid
  • EC 3.4.22.2
  • EINECS 232-627-2
  • Nematolyt
  • Papain
  • Papainase
  • Papaya Enzyme
  • Papayotin
  • Summetrin
  • Tromasin
  • UNII-A236A06Y32
  • Vegetable pepsin
  • Velardon
  • Vermizym

Systematic Names

  • A purified proteolytic substance derived from Carica papaya Linn'e (Fam. Caricaceae)
  • Papain

Superlist Name

  • Papain

Mixture Name

  • Panafil

Registry Numbers

CAS Registry Number

  • 9001-73-4

FDA UNII

  • A236A06Y32

Other Registry Numbers

  • 125054-90-2
  • 8050-04-2
  • 8057-83-8
  • 9002-59-9
  • 9086-65-1

System Generated Number

  • 0009001734

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 71mg/kg (71mg/kg) GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS Journal of Clinical Gastroenterology. Vol. 9, Pg. 127, 1987.
mouse LD50 oral 12500mg/kg (12500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 51, Pg. 27, 1955.
mouse LDLo intraperitoneal 50mg/kg (50mg/kg)   Toxicon. Vol. 19, Pg. 851, 1981.
rat LD50 oral > 4gm/kg (4000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 126, 1966.