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Substance Name: Phospholipase A2
RN: 9001-84-7

Note

  • Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.
 

Classification Code

  • Natural Product
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Links to Resources

Names and Synonyms

MeSH Heading

  • Phospholipases A2

Synonyms

  • E.C. 3.1.1.4
  • EINECS 232-637-7
  • Haemachatus haemachatus phospholipase A2
  • Lecithinase A
  • Naja nigricollis phospholipase A2
  • Phosphatidase
  • Phosphatidolipase
  • Phospholipase A
  • Phospholipase A(sub 2)
  • Phospholipase A2
  • Venom, Hemachatus haemachatus snake, phospholipase A2
  • Venom, Naja nigricollis snake, phospholipase A2

Systematic Names

  • Phospholipase A2
  • Phospholipase A2, from Hemachatus haemachatus snake venom
  • Phospholipase A2, from Naja nigricollis venom

Registry Numbers

CAS Registry Number

  • 9001-84-7

System Generated Number

  • 0009001847

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4900ug/kg (4.9mg/kg)   Toxicon. Vol. 18, Pg. 529, 1980.
mouse LD50 intraperitoneal 5mg/kg (5mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 232, Pg. 244, 1957.
mouse LD50 intravenous 630ug/kg (0.63mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: HEMORRHAGE
Biochemical Pharmacology. Vol. 29, Pg. 1565, 1980.
mouse LD50 intravenous 7500ug/kg (7.5mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 538, 1957.
mouse LD50 intravenous 8600ug/kg (8.6mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Biochemical Pharmacology. Vol. 29, Pg. 1565, 1980.
mouse LD50 subcutaneous 1200ug/kg (1.2mg/kg)   Toxicon. Vol. 24, Pg. 1001, 1986.
mouse LDLo unreported 1mg/kg (1mg/kg)   Toxicon. Vol. 13, Pg. 90, 1975.
rat LD50 intracrebral 2500ng/kg (0.0025mg/kg)   Toxicon. Vol. 24, Pg. 679, 1986.
rat LD50 parenteral 1286ng/kg (0.001286mg/kg) BEHAVIORAL: ANTICONVULSANT Toxicon. Vol. 19, Pg. 61, 1981.
rat LD50 parenteral 43ug/kg (0.043mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: AGRANULOCYTOSIS
Biochemical Pharmacology. Vol. 29, Pg. 1565, 1980.