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Substance Name: Streptokinase [INN:BAN]
RN: 9002-01-1
UNII: 8X1OXL3SNU

Note

  • Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase ( STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Natural Product

Names and Synonyms

Name of Substance

  • Streptokinase [INN:BAN]

MeSH Heading

  • Streptokinase

Synonyms

  • Awelysin
  • Co-enzyme obtained from cultures of various strains of Streptococcus haemolyticus
  • EINECS 232-647-1
  • Estreptoquinasa
  • Estreptoquinasa [INN-Spanish]
  • Kabikinase
  • Streptase
  • Streptochinasi
  • Streptochinasi [DCIT]
  • Streptococcal fibrinolysin
  • Streptokinase
  • Streptokinasum
  • Streptokinasum [INN-Latin]
  • UNII-8X1OXL3SNU

Systematic Names

  • Co-enzyme obtained from cultures of various strains of Streptococcus haemolyticus.
  • Kinase (enzyme-activating), strepto-

Registry Numbers

CAS Registry Number

  • 9002-01-1

FDA UNII

  • 8X1OXL3SNU

System Generated Number

  • 0009002011

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo subcutaneous 600iu/kg (600iu/kg)   JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1314, 1984.
man TDLo intravenous 562500iu/kg (562500iu/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
JAMA, Journal of the American Medical Association. Vol. 252, Pg. 1314, 1984.
mouse LD50 intraperitoneal 4200mg/kg (4200mg/kg)   Folia Haematologica Vol. 103, Pg. 445, 1976.
mouse LD50 intravenous 3700mg/kg (3700mg/kg)   Farmakologiya i Toksikologiya Vol. 43, Pg. 671, 1980.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Folia Haematologica Vol. 103, Pg. 445, 1976.
rat LD50 intravenous 2gm/kg (2000mg/kg)   Farmakologiya i Toksikologiya Vol. 43, Pg. 671, 1980.