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Substance Name: Dehydrogenase, tetrahydrofolate
RN: 9002-03-3

Note

  • An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
 
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Names and Synonyms

MeSH Heading

  • Tetrahydrofolate Dehydrogenase

Systematic Name

  • Dehydrogenase, tetrahydrofolate

Registry Numbers

CAS Registry Number

  • 9002-03-3

System Generated Number

  • 0009002033