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Substance Name: Thrombin
RN: 9002-04-4
UNII: 6K15ABL77G

Notes

  • An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
  • Inhibited by antithrombin III.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Coagulants
  • Hematologic Agents
  • Hemostatics
  • Mutation Data
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources

Names and Synonyms

Name of Substance

  • Factor IIa
  • Thrombin
  • Thrombin human
  • Thrombin, topical

Synonyms

  • Blood-coagulation factor II, activated
  • Blood-coagulation factor IIa
  • Bovine thrombin
  • E.C. 3.4.21.5
  • E.C. 3.4.4.13
  • EINECS 232-648-7
  • Evithrom
  • Factor IIa
  • Fibrinogenase
  • Thrombase
  • Thrombin
  • Thrombin II
  • Thrombin JMI
  • Thrombin, topical (recombinant)
  • Thrombin-C
  • Thrombinar
  • Thrombofort
  • Thrombostat
  • Tropostasin
  • UNII-6K15ABL77G

Systematic Name

  • Thrombin

Registry Numbers

CAS Registry Number

  • 9002-04-4

FDA UNII

  • 6K15ABL77G

Other Registry Numbers

  • 105881-84-3
  • 53028-63-0
  • 8050-02-0
  • 8059-56-1
  • 9014-41-9

System Generated Number

  • 0009002044

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 50mL/kg (50mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.
mouse LD50 intravenous 7771ug/kg (7.771mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 669, 1988.
mouse LD50 skin > 3gm/kg (3000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 1, Pg. 272, 1973.
mouse LD50 subcutaneous > 50mL/kg (50mL/kg)   Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.
rat LD50 intraperitoneal > 40mL/kg (40mL/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.
rat LD50 subcutaneous > 40mL/kg (40mL/kg)   Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.