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Substance Name: Corticotropin [USP:INN:BAN]
RN: 9002-60-2
InChIKey: IDLFZVILOHSSID-OVLDLUHVSA-N

Note

  • An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).

Molecular Formula

  • Unspecified

Molecular Weight

  • 4541.0658
 

Classification Codes

  • Diagnostic Aid (Adrenocortical Insufficiency)
  • Glucocorticoid
  • Hormone (Adrenocorticotropic)
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Natural Product
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Corticotropin
  • Corticotropin [USP:INN:BAN]

MeSH Heading

  • Adrenocorticotropic hormone

Synonyms

  • Acethropan
  • Acortan
  • Acorto
  • ACTH
  • Acthar
  • Acton
  • Actonar
  • Adrenal cortex hormone
  • Adrenocorticotrophic hormone
  • Adrenocorticotrophin
  • Adrenocorticotropic hormone
  • Adrenocorticotropin
  • Adrenomone
  • Adrenotrophin
  • Alfatrofin
  • CCRIS 6752
  • Cibacthen
  • Corstiline
  • Corticotrofina
  • Corticotrofina [INN-Spanish]
  • Corticotrophin
  • Corticotrophine
  • Corticotrophine [INN-French]
  • Corticotrophinum
  • Corticotrophinum [INN-Latin]
  • Corticotropin
  • Corticotropin, repository
  • Corticotropin-like substances
  • Corticotropina
  • Corticotropina [DCIT]
  • Corticotropine
  • Corticotropinum
  • Cortigel
  • Cortiphyson
  • Cortrophin
  • Depo-Acth
  • Duracton
  • Dynamone
  • EINECS 232-659-7
  • Exacthin
  • HSDB 7773
  • Humactid
  • Isactid
  • Nuvacthen
  • Pituitary gland adreno cortico-tropic hormone
  • ProActon
  • Purified Cortrophin gel
  • Reacthin
  • Solacthyl
  • Tubex

Systematic Names

  • Adrenocorticotropin
  • Corticotropin

Registry Numbers

CAS Registry Number

  • 9002-60-2

Other Registry Numbers

  • 55127-96-3
  • 8049-37-4
  • 8049-43-2
  • 8049-68-1
  • 8049-86-3
  • 8049-87-4
  • 9006-61-5
  • 9040-10-2

System Generated Number

  • 0009002602

Structure Descriptors

InChI

1S/C207H308N56O58S/c1-108(2)89-140(186(302)240-135(69-74-163(279)280)182(298)254-149(204(320)321)94-117-43-20-15-21-44-117)250-193(309)152-54-35-86-262(152)202(318)147(92-116-41-18-14-19-42-116)252-171(287)114(11)230-175(291)132(66-71-160(273)274)234-170(286)113(10)231-191(307)150(105-265)255-183(299)136(70-75-164(281)282)241-190(306)146(98-165(283)284)249-180(296)133(67-72-161(275)276)235-169(285)112(9)229-157(270)101-225-174(290)145(97-156(213)269)251-194(310)153-55-36-87-263(153)203(319)148(93-119-60-64-123(268)65-61-119)253-199(315)167(110(5)6)257-185(301)129(49-26-30-79-210)243-198(314)168(111(7)8)259-196(312)155-57-38-85-261(155)201(317)139(53-34-83-223-207(218)219)244-178(294)130(51-32-81-221-205(214)215)237-177(293)128(48-25-29-78-209)236-176(292)127(47-24-28-77-208)232-158(271)103-227-197(313)166(109(3)4)258-195(311)154-56-37-84-260(154)200(316)138(50-27-31-80-211)233-159(272)102-226-173(289)143(95-120-99-224-126-46-23-22-45-124(120)126)247-179(295)131(52-33-82-222-206(216)217)238-187(303)142(90-115-39-16-13-17-40-115)246-189(305)144(96-121-100-220-107-228-121)248-181(297)134(68-73-162(277)278)239-184(300)137(76-88-322-12)242-192(308)151(106-266)256-188(304)141(245-172(288)125(212)104-264)91-118-58-62-122(267)63-59-118/h13-23,39-46,58-65,99-100,107-114,125,127-155,166-168,224,264-268H,24-38,47-57,66-98,101-106,208-212H2,1-12H3,(H2,213,269)(H,220,228)(H,225,290)(H,226,289)(H,227,313)(H,229,270)(H,230,291)(H,231,307)(H,232,271)(H,233,272)(H,234,286)(H,235,285)(H,236,292)(H,237,293)(H,238,303)(H,239,300)(H,240,302)(H,241,306)(H,242,308)(H,243,314)(H,244,294)(H,245,288)(H,246,305)(H,247,295)(H,248,297)(H,249,296)(H,250,309)(H,251,310)(H,252,287)(H,253,315)(H,254,298)(H,255,299)(H,256,304)(H,257,301)(H,258,311)(H,259,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,320,321)(H4,214,215,221)(H4,216,217,222)(H4,218,219,223)/t112-,113-,114-,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,166-,167-,168-/m0/s1

InChIKey

IDLFZVILOHSSID-OVLDLUHVSA-N

Smiles

CSCC[C@H](\N=C(/O)\[C@H](CO)\N=C(/O)\[C@H](Cc1ccc(O)cc1)\N=C(/O)\[C@@H](N)CO)\C(=N\[C@@H](CCC(=O)O)\C(=N\[C@@H](Cc2cnc[nH]2)\C(=N\[C@@H](Cc3ccccc3)\C(=N\[C@@H](CCCNC(=N)N)\C(=N\[C@@H](Cc4c[nH]c5ccccc45)\C(=N\C\C(=N\[C@@H](CCCCN)C(=O)N6CCC[C@H]6\C(=N\[C@@H](C(C)C)\C(=N\C\C(=N\[C@@H](CCCCN)\C(=N\[C@@H](CCCCN)\C(=N\[C@@H](CCCNC(=N)N)\C(=N\[C@@H](CCCNC(=N)N)C(=O)N7CCC[C@H]7\C(=N\[C@@H](C(C)C)\C(=N\[C@@H](CCCCN)\C(=N\[C@@H](C(C)C)\C(=N\[C@@H](Cc8ccc(O)cc8)C(=O)N9CCC[C@H]9\C(=N\[C@@H](CC(=N)O)\C(=N\C\C(=N\[C@@H](C)\C(=N\[C@@H](CCC(=O)O)\C(=N\[C@@H](CC(=O)O)\C(=N\[C@@H](CCC(=O)O)\C(=N\[C@@H](CO)\C(=N\[C@@H](C)\C(=N\[C@@H](CCC(=O)O)\C(=N\[C@@H](C)\C(=N\[C@@H](Cc%10ccccc%10)C(=O)N%11CCC[C@H]%11\C(=N\[C@@H](CC(C)C)\C(=N\[C@@H](CCC(=O)O)\C(=N\[C@@H](Cc%12ccccc%12)C(=O)O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O)\O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo unreported 240mg/kg/16W- (240mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Lancet. Vol. 1, Pg. 901, 1984.