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Substance Name: Poloxalene [USAN:USP:INN:BAN]
RN: 9003-11-6

Note

  • A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.

Molecular Formula

  • (C3-H6-O.C2-H4-O)x-

Molecular Weight

  • 102.132
 

Classification Codes

  • Anti-Infective Agents
  • Cathartics
  • Disinfectants
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Pharmaceutic Aid (Ointment Base)
  • Pharmaceutic Aid (Suppository Base)
  • Pharmaceutic Aid (Surfactant)
  • Pharmaceutic Aid (Tablet Binder and Emulsifying Agent)
  • Pharmaceutic Aid (Tablet Coating Agent)
  • Rheologic Agent to Lower Blood Viscosity and Improve Microvascular Blood Flow
  • Surface-Active Agents
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Name of Substance

  • Meroxapol 105
  • PEG/PPG-125/30 Copolymer
  • Poloxalene
  • Poloxalene [USAN:USP:INN:BAN]
  • Poloxalkol
  • Poloxamer 101
  • Vepoloxamer [USAN]

MeSH Heading

  • Poloxalene

Synonyms

  • 75-H-1400
  • Bloat guard
  • BSP 5000
  • Ethylene oxide, propylene oxide block polymer
  • HSDB 7222
  • Lutrol F
  • MST-188
  • NSC 63908
  • Pluracare
  • Pluronic
  • Poloxalene
  • Poloxamer
  • Poloxamer-188
  • Polyethylene glycol, propoxylated
  • Polyethylene-polypropylene glycol
  • Polyoxyethylene-oxy-propylene
  • Polyoxyethylene-oxy-propylene [French]
  • Proxanol Tsl-3
  • RC 102
  • SK&F 18,667
  • SKF 18667
  • Therabloat
  • UNII-199SZS8E2Q
  • UNII-1AZW43116L
  • UNII-52901V8XAR
  • UNII-66UUC8WX0D
  • UNII-68T8I45V23
  • UNII-ETS9O8IMRZ
  • UNII-JP0CK963E0
  • UNII-P5QZM4T259
  • Vepoloxamer

Systematic Names

  • Glycols, polyethylene-polypropylene
  • Oxirane, 2-methyl-, polymer with oxirane
  • Oxirane, methyl-, polymer with oxirane
  • Polyethylene-polypropylene glycol

Superlist Names

  • Poly(ethylene oxide-co-propylene oxide)
  • Polyoxyethylene - polyoxypropylene copolymer

Registry Numbers

CAS Registry Number

  • 9003-11-6

FDA UNIIs

  • 199SZS8E2Q
  • 1AZW43116L
  • 52901V8XAR
  • 66UUC8WX0D
  • 68T8I45V23
  • ETS9O8IMRZ
  • JP0CK963E0
  • P5QZM4T259

Other Registry Numbers

  • 106717-66-2
  • 1087262-79-0
  • 1214718-60-1
  • 1220390-47-5
  • 124057-63-2
  • 125523-27-5
  • 12676-40-3
  • 12772-49-5
  • 1354714-46-7
  • 1359884-87-9
  • 1407593-02-5
  • 1426233-29-5
  • 1430143-53-5
  • 162627-00-1
  • 163032-64-2
  • 163063-49-8
  • 167267-50-7
  • 168018-54-0
  • 1700656-07-0
  • 170779-86-9
  • 172306-19-3
  • 1818351-41-5
  • 1851281-18-9
  • 186673-37-0
  • 1870006-85-1
  • 190735-22-9
  • 208342-25-0
  • 209682-92-8
  • 231627-80-8
  • 232598-91-3
  • 250780-00-8
  • 254903-86-1
  • 291775-89-8
  • 30600-73-8
  • 37211-19-1
  • 37211-20-4
  • 37211-21-5
  • 37211-22-6
  • 37211-23-7
  • 37211-24-8
  • 37221-18-4
  • 37265-39-7
  • 37307-38-3
  • 37331-16-1
  • 37331-17-2
  • 37341-81-4
  • 374624-82-5
  • 39277-80-0
  • 39316-56-8
  • 39316-57-9
  • 39364-13-1
  • 39387-54-7
  • 452069-47-5
  • 472960-66-0
  • 50643-24-8
  • 51312-31-3
  • 51569-27-8
  • 53637-72-2
  • 56730-46-2
  • 570369-25-4
  • 57219-38-2
  • 57571-70-7
  • 57971-91-2
  • 58968-65-3
  • 59494-33-6
  • 59794-22-8
  • 60328-61-2
  • 60407-69-4
  • 60976-75-2
  • 634588-40-2
  • 64104-17-2
  • 64940-96-1
  • 65187-10-2
  • 65380-70-3
  • 66746-25-6
  • 69070-95-7
  • 69256-70-8
  • 70213-25-1
  • 70644-95-0
  • 71343-56-1
  • 72319-37-0
  • 73158-62-0
  • 76050-76-5
  • 76364-46-0
  • 77448-18-1
  • 77752-09-1
  • 778599-53-4
  • 797786-13-1
  • 81180-56-5
  • 84931-05-5
  • 86249-84-5
  • 862582-70-5
  • 86304-35-0
  • 877037-78-0
  • 87912-55-8
  • 87912-56-9
  • 9003-12-7
  • 9009-02-3
  • 9009-03-4
  • 9009-04-5
  • 9009-05-6
  • 9009-06-7
  • 9010-49-5
  • 9010-97-3
  • 9015-66-1
  • 9050-44-6
  • 905305-59-1
  • 9061-69-2
  • 9067-43-0
  • 91858-59-2
  • 98932-37-7

System Generated Number

  • 0009003116

Molecular Formulas

Molecular Formula

  • (C3-H6-O.C2-H4-O)x-

Molecular Formula Fragments

  • C2-H4-O
  • C3-H6-O
  • COMPONENT

Structure Descriptors

Smiles

C1[C@@H](O1)C.C1CO1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 175mg/kg (175mg/kg)   Microvascular Research. Vol. 8, Pg. 320, 1974.
mouse LD50 oral 3gm/kg (3000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984.
mouse LD50 oral > 15gm/kg (15000mg/kg)   Drug and Chemical Toxicology. Vol. 1, Pg. 89, 1977/1978.
mouse LD50 oral 45gm/kg (45000mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970.
mouse LDLo intraperitoneal 5gm/kg (5000mg/kg)   Therapie. Vol. 14, Pg. 721, 1959.
mouse LDLo intravenous 6gm/kg (6000mg/kg)   Therapie. Vol. 14, Pg. 721, 1959.
mouse LDLo oral 15gm/kg (15000mg/kg)   Therapie. Vol. 14, Pg. 721, 1959.
rabbit LD50 oral 35gm/kg (35000mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970.
rat LC50 inhalation 320mg/m3/4H (320mg/m3) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
National Technical Information Service. Vol. OTS0539401,
rat LD50 oral 5700mg/kg (5700mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984.
rat LDLo intraperitoneal 10gm/kg (10000mg/kg)   Therapie. Vol. 14, Pg. 721, 1959.
rat LDLo oral 16gm/kg (16000mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970.