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Substance Name: Poloxalene [USAN:USP:INN:BAN]
RN: 9003-11-6
Note
- A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
Molecular Formula
- (C3-H6-O.C2-H4-O)x-
Molecular Weight
- 102.132
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Infective Agents
- Cathartics
- Disinfectants
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Pharmaceutic Aid (Ointment Base)
- Pharmaceutic Aid (Suppository Base)
- Pharmaceutic Aid (Surfactant)
- Pharmaceutic Aid (Tablet Binder and Emulsifying Agent)
- Pharmaceutic Aid (Tablet Coating Agent)
- Rheologic Agent to Lower Blood Viscosity and Improve Microvascular Blood Flow
- Surface-Active Agents
- TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Meroxapol 105
- PEG/PPG-125/30 Copolymer
- Poloxalene
- Poloxalene [USAN:USP:INN:BAN]
- Poloxalkol
- Poloxamer 101
- Vepoloxamer [USAN]
MeSH Heading
- Poloxalene
Synonyms
- 75-H-1400
- Bloat guard
- BSP 5000
- Ethylene oxide, propylene oxide block polymer
- HSDB 7222
- Lutrol F
- MST-188
- NSC 63908
- Pluracare
- Pluronic
- Poloxalene
- Poloxamer
- Poloxamer-188
- Polyethylene glycol, propoxylated
- Polyethylene-polypropylene glycol
- Polyoxyethylene-oxy-propylene
- Polyoxyethylene-oxy-propylene [French]
- Proxanol Tsl-3
- RC 102
- SK&F 18,667
- SKF 18667
- Therabloat
- UNII-199SZS8E2Q
- UNII-1AZW43116L
- UNII-52901V8XAR
- UNII-66UUC8WX0D
- UNII-68T8I45V23
- UNII-ETS9O8IMRZ
- UNII-JP0CK963E0
- UNII-P5QZM4T259
- Vepoloxamer
Systematic Names
- Glycols, polyethylene-polypropylene
- Oxirane, 2-methyl-, polymer with oxirane
- Oxirane, methyl-, polymer with oxirane
- Polyethylene-polypropylene glycol
Superlist Names
- Poly(ethylene oxide-co-propylene oxide)
- Polyoxyethylene - polyoxypropylene copolymer
Registry Numbers
CAS Registry Number
- 9003-11-6
FDA UNIIs
- 199SZS8E2Q
- 1AZW43116L
- 52901V8XAR
- 66UUC8WX0D
- 68T8I45V23
- ETS9O8IMRZ
- JP0CK963E0
- P5QZM4T259
Other Registry Numbers
- 106717-66-2
- 1087262-79-0
- 1214718-60-1
- 1220390-47-5
- 124057-63-2
- 125523-27-5
- 12676-40-3
- 12772-49-5
- 1354714-46-7
- 1359884-87-9
- 1407593-02-5
- 1426233-29-5
- 1430143-53-5
- 162627-00-1
- 163032-64-2
- 163063-49-8
- 167267-50-7
- 168018-54-0
- 1700656-07-0
- 170779-86-9
- 172306-19-3
- 1818351-41-5
- 1851281-18-9
- 186673-37-0
- 1870006-85-1
- 190735-22-9
- 208342-25-0
- 209682-92-8
- 231627-80-8
- 232598-91-3
- 250780-00-8
- 254903-86-1
- 291775-89-8
- 30600-73-8
- 37211-19-1
- 37211-20-4
- 37211-21-5
- 37211-22-6
- 37211-23-7
- 37211-24-8
- 37221-18-4
- 37265-39-7
- 37307-38-3
- 37331-16-1
- 37331-17-2
- 37341-81-4
- 374624-82-5
- 39277-80-0
- 39316-56-8
- 39316-57-9
- 39364-13-1
- 39387-54-7
- 452069-47-5
- 472960-66-0
- 50643-24-8
- 51312-31-3
- 51569-27-8
- 53637-72-2
- 56730-46-2
- 570369-25-4
- 57219-38-2
- 57571-70-7
- 57971-91-2
- 58968-65-3
- 59494-33-6
- 59794-22-8
- 60328-61-2
- 60407-69-4
- 60976-75-2
- 634588-40-2
- 64104-17-2
- 64940-96-1
- 65187-10-2
- 65380-70-3
- 66746-25-6
- 69070-95-7
- 69256-70-8
- 70213-25-1
- 70644-95-0
- 71343-56-1
- 72319-37-0
- 73158-62-0
- 76050-76-5
- 76364-46-0
- 77448-18-1
- 77752-09-1
- 778599-53-4
- 797786-13-1
- 81180-56-5
- 84931-05-5
- 86249-84-5
- 862582-70-5
- 86304-35-0
- 877037-78-0
- 87912-55-8
- 87912-56-9
- 9003-12-7
- 9009-02-3
- 9009-03-4
- 9009-04-5
- 9009-05-6
- 9009-06-7
- 9010-49-5
- 9010-97-3
- 9015-66-1
- 9050-44-6
- 905305-59-1
- 9061-69-2
- 9067-43-0
- 91858-59-2
- 98932-37-7
System Generated Number
- 0009003116
Molecular Formulas
Molecular Formula
- (C3-H6-O.C2-H4-O)x-
Molecular Formula Fragments
- C2-H4-O
- C3-H6-O
- COMPONENT
Structure Descriptors
Smiles
C1[C@@H](O1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 175mg/kg (175mg/kg) | Microvascular Research. Vol. 8, Pg. 320, 1974. | |
| mouse | LD50 | oral | 3gm/kg (3000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. |
| mouse | LD50 | oral | > 15gm/kg (15000mg/kg) | Drug and Chemical Toxicology. Vol. 1, Pg. 89, 1977/1978. | |
| mouse | LD50 | oral | 45gm/kg (45000mg/kg) | Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970. | |
| mouse | LDLo | intraperitoneal | 5gm/kg (5000mg/kg) | Therapie. Vol. 14, Pg. 721, 1959. | |
| mouse | LDLo | intravenous | 6gm/kg (6000mg/kg) | Therapie. Vol. 14, Pg. 721, 1959. | |
| mouse | LDLo | oral | 15gm/kg (15000mg/kg) | Therapie. Vol. 14, Pg. 721, 1959. | |
| rabbit | LD50 | oral | 35gm/kg (35000mg/kg) | Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970. | |
| rat | LC50 | inhalation | 320mg/m3/4H (320mg/m3) | LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | National Technical Information Service. Vol. OTS0539401, |
| rat | LD50 | oral | 5700mg/kg (5700mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. |
| rat | LDLo | intraperitoneal | 10gm/kg (10000mg/kg) | Therapie. Vol. 14, Pg. 721, 1959. | |
| rat | LDLo | oral | 16gm/kg (16000mg/kg) | Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970. |