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Substance Name: Elastase [JAN]
RN: 9004-06-2

Notes

  • A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
  • A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.
  • An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources

Names and Synonyms

Name of Substance

  • Elastase
  • Elastase [JAN]

MeSH Headings

  • Leukocyte Elastase
  • Pancreatic elastase II

Synonyms

  • E.C. 3.4.2.1.11
  • E.C. 3.4.21.11
  • E.C. 3.4.21.36
  • E.C. 3.4.21.37
  • E.C. 3.4.24.65
  • E.C. 3.4.4.7
  • EINECS 232-670-7
  • Elastase
  • Elastase 2
  • Elaszym
  • Macrophage metalloelastase
  • Matrix metalloproteinase-12
  • Medullasin
  • MMP 12
  • MMP-12
  • Neutrophil Elastase
  • Pancreatopeptidase E
  • Peptidase, pancreato-, E
  • Proteinase, bone marrow serine

Systematic Names

  • Elastase
  • Protease obtained from dried porcine pancreas

Registry Numbers

CAS Registry Number

  • 9004-06-2

Other Registry Numbers

  • 139074-64-9
  • 74505-35-4
  • 75603-19-9
  • 80966-01-4
  • 83682-98-8
  • 9001-21-2
  • 9033-37-8

System Generated Number

  • 0009004062

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 37mg/kg (37mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
mouse LD50 intravenous 57mg/kg (57mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
rat LD50 intraperitoneal 78mg/kg (78mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
rat LD50 intravenous 85mg/kg (85mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
rat LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.