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Substance Name: Chymotrypsin [USP:INN:BAN:JAN]
RN: 9004-07-3
UNII: BVS505O332

Note

  • A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme (Proteolytic)
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources

Names and Synonyms

Name of Substance

  • Chymotrypsin
  • Chymotrypsin [USP:INN:BAN:JAN]

MeSH Heading

  • Chymotrypsin

Synonyms

  • Alfapsin
  • alpha Chymar
  • alpha-Chymar ophth
  • alpha-Chymotrypsin
  • Avazyme
  • Catarase
  • Chimotripsina
  • Chimotripsina [DCIT]
  • Chymar
  • Chymolase
  • Chymotest
  • Chymotrypsin
  • Chymotrypsin A
  • Chymotrypsin B
  • Chymotrypsine
  • Chymotrypsine [INN-French]
  • Chymotrypsinum
  • Chymotrypsinum [INN-Latin]
  • Chymozym
  • E.C. 3.4.21.1
  • E.C. 3.4.4.5
  • E.C. 3.4.4.6
  • EC 3 4 21 1
  • EC 3 4 4 5
  • EC 3 4 4 6
  • EINECS 232-671-2
  • Enzeon
  • HSDB 3036
  • Impral
  • Kimopsin
  • Kimoral
  • Quimar
  • Quimotrase
  • Quimotripsina
  • Quimotripsina [INN-Spanish]
  • UNII-BVS505O332
  • Zolyse

Systematic Name

  • Chymotrypsin

Mixture Name

  • Orenzyme

Registry Numbers

CAS Registry Number

  • 9004-07-3

FDA UNII

  • BVS505O332

Other Registry Numbers

  • 8049-46-5
  • 9025-29-0
  • 9062-30-0
  • 9067-81-6

System Generated Number

  • 0009004073

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 50000units/kg (50000units/kg) CARDIAC: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BLOOD: HEMORRHAGE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956.
mouse LD50 intramuscular 104mg/kg (104mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
mouse LD50 intravenous 89mg/kg (89mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
mouse LD50 oral > 6gm/kg (6000mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
mouse LD50 subcutaneous 185mg/kg (185mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
rabbit LD50 intravenous 24000units/kg (24000units/kg) GASTROINTESTINAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BLOOD: HEMORRHAGE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956.
rat LD50 intramuscular 116mg/kg (116mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
rat LD50 intraperitoneal 65100ug/kg (65.1mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 42, 1950.
rat LD50 intravenous 84mg/kg (84mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.
rat LD50 subcutaneous 250mg/kg (250mg/kg)   Drugs in Japan Vol. 6, Pg. 202, 1982.