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Substance Name: Insulin, protamine zinc [USP]
RN: 9004-17-5

Note

  • A Long-acting insulin with an approximate time of onset of 7 hours and duration of action 36 hours, consisting of bovine or pork insulin reacted with zinc chloride and protamine to form a protein complex from which insulin is slowly released. (Dorland, 28th ed)

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antidiabetic
  • Drug / Therapeutic Agent
  • Hormone
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Insulin, NPH
  • Insulin, protamine zinc [USP]

MeSH Heading

  • Insulin, NPH

Synonyms

  • Basal insulin detemir
  • Depo-insulin
  • Deposulin
  • Humulin N-U 100
  • Insulatard Insulin
  • Insulin injection, isophane (aqueous suspension)
  • Insulin retard RI
  • Insulin zinc protaminate
  • Insulin zinc protamine
  • Insulin zinc protamine injection (aqueous suspension)
  • Insulin, depo
  • Insulin, isophane
  • Insulin, Long-Acting
  • Insulin, NPH
  • Insulin, protamine zinc
  • Insulina isofana
  • Insulina isofana [INN-Spanish]
  • Insulina-zinco protaminato iniettabile
  • Insulina-zinco protaminato iniettabile [DCIT]
  • Insulini zinci protaminati injectio
  • Insulini zinci protaminati injectio [INN-Latin]
  • Insulini zinco protamini aquosuspensa
  • Insulinum isophanum
  • Insulyl-retard
  • Inyectable de insulina cinc protamina
  • Inyectable de insulina cinc protamina [INN-Spanish]
  • Isophane insulin
  • Isophane insulin suspension
  • Isophane insuline
  • Isophane insuline [INN-French]
  • Isophanum insulinum
  • Isophanum insulinum [INN-Latin]
  • NPH
  • NPH 50 insulin
  • NPH humulin insulin
  • NPH Iletin
  • NPH insulin
  • Prep. injectable d'insuline zinc protam.
  • Prep. injectable d'insuline zinc protam. [INN-French]
  • Protamine zinc insulin
  • Protamine zinc insulin injection
  • Protamine zinc insulin suspension
  • Protaphane HM
  • PZI insulin
  • Suspension injectable d'insuline protamine zinc
  • Zinc protamine insulin
  • Zinc-protamininsulinum
  • Zine, with protamine insulin

Systematic Name

  • Insulin protamine zinc

Registry Numbers

CAS Registry Number

  • 9004-17-5

Other Registry Numbers

  • 8052-74-2
  • 8053-24-5

System Generated Number

  • 0009004175

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 195iu/kg (195iu/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 379, 1965.
rat LD50 intraperitoneal 830ug/kg (0.83mg/kg)   Toxicology and Applied Pharmacology. Vol. 4, Pg. 631, 1962.
rat LD50 intraperitoneal 830ug/kg (0.83mg/kg) BEHAVIORAL: ATAXIA

ENDOCRINE: HYPOGLYCEMIA
Toxicology and Applied Pharmacology. Vol. 4, Pg. 631, 1962.